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Burns & WoundsAn exploration of recombinant human growth hormone (rhGH) effects on the metabolism of branch chain amino acid revealed it could promote systemic protein synthesis. A synergy of nutritional support and rhGH treatment may even produce rapid improvement for a burn patient. Additional studies demonstrate that rhGH treatment can enhance the wound-healing rate, improve anabolism and possibly reduce length of a hospital stay. Review current research and medical articles on burns and wounds to learn more about various treatment options. Low Serum Testosterone and Mortality in Male Veterans.pdf This study
used a clinical database to identify men
older than 40 years with repeated
testosterone levels obtained from October 1,
1994 to December 31, 1999, and without
diagnosed prostate cancer. It concluded
that low testosterone levels were associated
with increased mortality in male veterans.
Further prospective studies are needed to
examine the association between low
testosterone levels and mortality. This study
focused on severely-burned patients. It
looked at combining administration of
glutamine (Gln) and recombinant human growth
hormone (rhGH) to see if it could be
beneficial to the elevation of the plasma
Gln level in these patients. This study
provides further support that carbohydrate
and fat metabolism influence cardiac outcome
and provides new evidence that dietary
modification prior to coronary artery bypass
surgery can shorten the hospital stay.
Thirty-eight severely burned patients were
studied to investigate the changes in
protein catabolism and immunocompetence in
such patients postoperatively. It also
observed the therapeutic effect of
recombinant human growth hormone (rhGH) in
these patients. It concluded that nutrition
support and rhGH treatment may produce rapid
improvement for the patients with regard to
their conditions Twenty
patients undergoing abdominal surgery
participated in this placebo-controlled
randomized double-blind trial. Each patient
was given human growth hormone
subcutaneously for a period of days leading
up to and following the operation.
Recombinant Human Growth Hormone Treatment
in Elderly Patients Undergoing Elective
Total Hip Replacement.pdf This study
concludes that recombinant human growth
hormone (rhGH) has a beneficial effect on
metabolism in patients who are severely
burned. Hyperglycemia, however, is apt to
occur and water, Na(+), Cl(-) retention are
suggested. Fifty patients were studied. Fifty
severely-burned patients were enrolled in
this study, the aim of which was to explore
the effects of recombinant human growth
hormone (rhGH) on the metabolism of branch
chain amino acid when applied
postoperatively. The Influence of Recombinant Human Growth Hormones on the Systemic Metabolism After Severe Burn.pdf The
conclusion of this study involving
twenty-four burn patients was that a small
dose of recombinant human growth hormone
could promote systemic protein synthesis
with no side effects on blood glucose
levels. Testosterone Administration in Severe Burns Ameliorates Muscle Catabolism.pdf The aim of
this study was to assess the effects of
testosterone administration on muscle
protein metabolism after severe burn
injury. It concluded that restoration of
blood testosterone can ameliorate the muscle
catabolism of severe burn injury with normal
feedings. The aim of
this study was to evaluate the additive
effects of rhGH and GLN on plasma amino
acids postoperatively. It concluded that the
combined treatment of growth hormone and
glutamine has additive effects on
AV-balances of amino acids postoperatively,
whereas nitrogen balance is not further
improved when adding glutamine to rhGH
treatment. The
results of this study suggest that
preoperative administration of rhGH may have
a role in preventing the diaphragmatic
dysfunction associated with infrarenal
aortic cross-clamping and revascularization. Hormonal Effects on Skin Aging.pdf This
article reviews the effect of decreasing
hormone levels on the skin and the possible
benefits of hormone replacement therapy (HRT).
It also discusses the positive effects
Growth Hormone and estrogen can have on
wound healing. Growth Hormone, Burns and Tissue Healing.pdf This
article will review the effects of GH on
burn wound repair and gut healing. Studies
on GH have shown a significant reduction in
wound-healing times in burned patients given
GH at a dose of 0.6 IU/kg/day (0.2
mg/kg/day). At this dose, other studies have
shown no increase in mortality, and a number
of beneficial effects in critically burned
children have been demonstrated. Mechanism of Recombinant Human Growth Hormone Accelerating Burn Wound Healing in Burn Patients.pdf The aim of
this study was to investigate the mechanism
of recombinant human growth hormone (rhGH)
in acceleration of burn wound healing. It
concluded that the application of rhGH in
burn patients could improve the serum
concentration of GH and IFG-1, promote DNA
synthesis and PCNA and EFGR expression of
epithelium, so that re-epithelialization of
the burn wound could be accelerated. According
to this study, the results demonstrate no
evidence for an increased risk of tumor
recurrence after rhGH treatment for a short
period of time after removal of a
gastrointestinal adenocarcinoma. Therefore,
the positive metabolic effects of rhGH
application can be used safely in the
treatment of the postoperative catabolic
state in the patient groups investigated. Depression of Liver Protein Synthesis During Surgery is Prevented by Growth Hormone.pdf This study
was undertaken to elucidate the specific
effects of growth hormone (GH) on liver
protein metabolism in humans during
surgery. It concluded that GH pretreatment
decreases hepatic free amino acid
concentrations and preserves liver protein
synthesis during surgery. This pilot
study indicates that rhGH administered
preoperatively has beneficial effects on
skeletal muscle and respiratory function and
may be more useful than postoperative rhGH
administration alone. The aim of
this study was to investigate the impact of
growth hormone, alone and in combination
with insulin, on the protein kinetics of
patients with upper gastrointestinal (GI)
tract cancer who have undergone surgery and
are receiving total parenteral nutrition (TPN).
It concluded that growth hormone and GH plus
insulin regimens improve protein kinetic
parameters in patients with upper GI tract
cancer who are receiving TPN after
undergoing surgery. The Study of Growth Hormone on Wound Healing Rate in Adult Burns.pdf This study
examined the effects of recombinant human
growth hormone on wound healing in forty-two
adult burn patients. Its findings showed
that rhGH could enhance the wound healing
rate and improve anabolism. The length of
hospital stay could also be reduced. From this
study it could be demonstrated both
clinically and histologically that systemic
application of growth hormone results in a
statistically significantly more rapid
healing of the skin graft donor sites by 2
days earlier than in the control group. This study
concluded that perioperative hGH treatment
of younger patients undergoing major
abdominal surgery preserved limb lean tissue
mass, increased postoperative muscular
strength, and reduced long-term
postoperative fatigue. The Behavior of Atherogenic Indices Under the Effect of Growth Hormone in Postoperative Disease.pdf Results of
this study show that, while in the control
group the atherogenic values increased to
pathologic levels, in the treatment group,
these values stabilized in the physiological
limits. This
article concludes that rhGH treatment is a
possible strategy that could be used with
malnourished patients who are awaiting lung
transplantation. It can improve the
nutritional status and respiratory muscle
function to prevent recurring respiratory
infection and postoperative complications
favored by malnutrition and possibly to
decrease the length of hospital stay. This study
evaluated the effects of perioperative
biosynthetic growth hormone (GH) treatment
on short- and long-term changes in body
composition and on nutritional intake. The Use of Growth Hormone in the Treatment of Extensive Burns: A Case Report.pdf The
authors report the case of a 12-year-old boy
with an electrical arc burn of 81% of the
BSA, 60% of the BSA being full thickness
loss. The treatment was well tolerated
except for mild insulinoresistance, which
could be easily corrected by slightly
increasing the insulin added to glucose
solutions. Effect of Growth Hormone Therapy in Burn Patients on Conservative Treatment.pdf This study
observed thirteen patients with second and
third degree burns who received recombinant
human growth hormone (rhGH) for two weeks in
addition to standard conservative treatment
and nine patients who were managed with
standard conservative treatment only. The
observations suggest significant benefits of
short term rhGH treatment in burn patients
on conservative management. To
determine the effects of recombinant human
growth hormone (GH) on postoperative amino
acids metabolism, this study performed a
placebo-controlled randomized double-blind
trial in 18 patients after elective
gastrectomy or colectomy. The results
demonstrated that GH can increase the uptake
of amino acid from forearm and decrease the
excreation of 3-methylhistidine in urine
after operation, but did not disturb the
balance of amino acids in plasma. Estradiol Accelerates Functional Endothelial Recovery After Arterial Injury.pdf This study
concluded that estrogen accelerates
functional endothelial recovery after
barotraumatic deendothelializing injury.
These findings, along with the recent
demonstration of estrogen receptor
expression by endothelial cells, suggest
that the antiatherogenic action of estrogen
may be mediated in part through direct
effects on endothelial cells. Effects of Human Growth Hormone on the Catabolic State After Surgical Trauma.pdf The aims
of these studies were: (1) to determine if
the protein catabolic response after a major
or moderate surgical trauma can be
restrained by the administration of
exogenous human growth hormone (hGH); (2) to
determine if the administration of hGH can
improve systemic host defenses, thus
reducing the risk of infection, and (3)
given that the postoperative fatigue
syndrome (POF) is mediated by the endocrino-metabolic
response to surgery we attempt to determine
if the administration of hGH can prevent or
reduce POF. This
article discusses a study of ten massively
burned patients with full-thickness burns
covering more than 40% of total body surface
area. It examined the efficacy of
recombinant human growth hormone (rhGH) on
burn patients for wound healing. The
results of this study indicate that both
forms of rhGH are effective in reducing
donor site healing time compared with
placebo and suggest that accelerating wound
healing is of clinical benefit because the
patients' own skin becomes rapidly available
for harvest and autografting. With this
increase in the rate of wound healing, the
total length of hospital stay can be reduced
by more than 25%. This study
concluded that GH administration accelerated
protein gain in stable adult patients
receiving aggressive nutritional therapy
without a significant increase in body fat
or a disproportionate expansion of ECW. GH
therapy accelerated nutritional repletion
and, therefore, may shorten the
convalescence of the malnourished patient
requiring a major surgical procedure.
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