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Depression Mid-life can be the linchpin to a score of depression complaints. Diminished hormones combined with poor lifestyle choices and dramatic, stressful changes in a patient’s personal or work life produce a litany of emotional upheavals. Exercise—running, swimming, dancing—as well as appropriate hormonal modulation may help restore youthful levels and create a beneficial impact on patients wrestling with depression. Review current research and medical articles on depression and these therapeutic approaches. Hormones and Sexuality During Transition to Menopause.pdf
This study confirms the observation
that sexual dysfunction increases
over the menopausal transition.
Several factors associated with
sexual dysfunction include low DHEAS,
absence of a sexual partner,
anxiety, and children under the age
of 18 living at home.
According to this article,
women may
not be the only ones who suffer the
effects of changing hormones. Some
doctors are noticing that their male
patients are reporting some of the
same symptoms that women experience
in menopause. Don’t Call it Male Menopause.pdf
As men start to age, their bodies
also start to undergo major changes.
They don't get hot flashes, but they
do experience hormonal,
physiological and chemical shifts
that can affect many aspects of
their lives. This article suggests
that you can call it aging; just
don't call it male menopause. Prevalence of Hypogonadism in Males Aged at Least 45 Years: The HIM study.pdf
According to this study, based on TT
concentration, the prevalence of
hypogonadism in men reporting to
primary care offices was estimated
to be 38.7%. The medical conditions
that occurred significantly more
frequently among hypogonadal men
than eugonadal men included
increased BMI, hypertension,
hyperlipidaemia, diabetes, and
asthma or COPD. As men age, they are
susceptible to conditions that share
many of the same symptoms similar to
hypogonadism. The presence of these
conditions may, in effect, mask
underlying hypogonadism and
negatively impact quality of life.
To
examine hormone levels after
androgen replacement therapy (ART)
in Japanese male patients with
hypogonadism, nine Japanese male
patients with hypogonadism (serum
total testosterone (tT) or free
testosterone (fT) levels of < or =
2.7 ng/mL or < or = 10 pg/mL,
respectively; average age, 59 years)
were enrolled. Management of Andropause: The Male Menopause.pdf
According to this article,
andropause is a syndrome of
physical, sexual, and psychological
symptoms in aging men due to a
gradual decline in serum
testosterone levels. Its symptoms
are more prominent in the presence
of concomitant medical disorders.
Testosterone replacement therapy
relieves these symptoms along with
improvement in bone and muscle mass,
sexual function, and quality of
life.
The
hormonal supplement DHEA could help
relieve mild to moderate depression
that starts in middle age, new
research shows. Workouts Can Lighten Heavy Hearts.pdf
According to this article, the
millions of Americans stricken each
year by debilitating depression may
want to consider running away from
their problem -- or walking,
swimming or dancing it away. Dehydroepiandrosterone Monotherapy in Midlife-Onset Major and Minor Depression.pdf
This
study found DHEA to be an effective
treatment for midlife-onset major
and minor depression.
The
results of this naturalistic study
indicate that chemical castration is
associated with a significant rise
in the plasma levels of Abeta and,
clinically, with increased
depression and anxiety scores. The
discontinuation of treatment is
associated with better cognitive
performance, most noticeably of
verbal memory. The performance of
subjects on the WL test was
negatively correlated with plasma
levels of Abeta, but the clinical
significance of this finding remains
to be determined.
Low Testosterone Common in Type 2
Diabetes Study: 1 in 3 Diabetic Men
May Suffer Low Sex Hormone
Levels.pdf
Quality of Life of Growth Hormone
(GH) Deficient Young Adults During
Discontinuation and Restart of GH
Therapy.pdf
The
preliminary observations report for
the first time in double-blind
fashion the efficacy of DHEA
augmentation in the management of
negative, depressive, and anxiety
symptoms of schizophrenia. The
findings from this study raise
important issues regarding the role
of neurosteroids in general, and
DHEA in particular, in the ongoing
symptomatology and pharmacotherapy
of schizophrenia.
Single and Combined Effects of
Growth Hormone and Testosterone
Administration on Measures of Body
Composition, Physical Performance,
Mood, Sexual Function, Bone
Turnover, and Muscle Gene Expression
in Healthy Older Men.pdf Do Omega-3 Fatty Acids Help in Depression?. pdf
This study concluded that despite
observational evidence linking
depression with reduced intake of
long-chain omega-3 fatty acids,
there is no convincing basis for
using these nutrients as a sole
treatment for the condition. There
is limited evidence suggesting that
long-chain omega-3 fatty acid
supplements might help to relieve
depression when given in addition to
existing antidepressantmedication.
However, this needs confirming
before they can recommend the
routine use of such supplements in
patients with depression.
This
article states that recent
availability of recombinant human
growth hormone (GH) has led to
intense investigation of the
consequences of adult GH deficiency
(GHD) and the effects of GH
replacement. These studies have led
to the identification of a
characteristic syndrome of GHD
consisting of decreased mood and
well-being, with alterations in body
composition and substrate
metabolism.
The Male Menopause and Mood:
Testosterone Decline and Depression
in the Aging Male--Is There a
Link?.pdf Bioavailable Testosterone and Depressed Mood in Older Men: The Rancho Bernardo Study.pdf
According to this study, it is
biologically plausible that
testosterone has an effect on
depression. As reviewed elsewhere,
androgen and estrogen binding sites
overlap in the brain. Testosterone
in the brain is extensively
converted to estradiol and DHT,
which binds to androgen receptors.
The complete absence of an
association between circulating
estradiol and mood scores makes the
thesis that the testosterone mood
association is mediated by
aromatization to estradiol
unattractive but does not entirely
exclude it. Clinical trials are
needed to further assess this
association.
The
purpose of this study was to
determine whether endogenous steroid
hormone levels are associated with
depressed mood in community-dwelling
older women. These results add to
the evidence that DHEA/S is a
neuroactive steroid and point to the
need for careful long-term clinical
trials of DHEA therapy in older
women with depressed mood. The Effects of 10 Years of Recombinant Human Growth Hormone (GH) in Adult GH-Deficient Patients.pdf
This
study concluded that GH treatment
for 10 yr in GHD adults resulted in
increased lean body and muscle mass,
a less atherogenic lipid profile,
reduced carotid intima media
thickness, and improved
psychological well-being. Health Benefits of Docosahexaenoic Acid (DHA).pdf
Fish
oil decreases the proliferation of
tumour cells, whereas arachidonic
acid, a longchain n-6 fatty acid,
increases their proliferation. These
opposite effects are also seen with
inflammation, particularly with
rheumatoid arthritis, and with
asthma. DHA has a positive effect on
diseases such as hypertension,
arthritis, atherosclerosis,
depression, adult-onset diabetes
mellitus, myocardial infarction,
thrombosis, and some cancers. Neuroactive Steroids: Mechanisms of Action and Neuropsychopharmacological Perspectives.pdf
This
article describes how neuroactive
steroids modulate neurotransmitter
receptors and addresses the
neuropsychopharmacological potential
that arises from the intracellular
crosstalk between genomic and
nongenomic steroid effects.
Neuroactive steroids could also have
a role in the response to stress and
the treatment of psychiatric
disorders, such as depression, and,
as they affect a broad spectrum of
behavioral functions through their
unique molecular properties, they
could constitute a yet unexploited
class of drugs. Double-Blind Treatment of Major Depression with Dehydroepiandrosterone.pdf
These
results of this study suggest
that DHEA treatment may
have significant antidepressant
effects in
some patients with major depression.
Further, larger-scale
trials are warranted. DHEA: A Biologist's Perspective.pdf
According to the author, it has been
proposed that replacement therapy
with DHEA to restore youthful levels
of DHEAS in older individuals might
have beneficial effects on a variety
of age-related conditions, such as
cardiovascular and neoplastic
diseases, diabetes, immune
dysfunction, muscular weakness, and
depression.
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