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Energy, Productivity & Well-Being As signs and symptoms of aging appear—from body composition, fatigue and libido loss to bone density, cognitive function and disturbed sleep—a patient’s quality of life wanes. Consequently, energy and overall productivity diminishes, resulting in a deflated sense of well-being. Even Corporate America has felt the impact of these patients’ sub par performance on the job. We now know how to remove the signs and symptoms of aging . . .without waiting until illness occurs to enjoy the effects of endocrine therapy. In a trial with healthy men (65 to 80 years old), coadministration of low-dose growth hormone and testosterone has shown to produce “beneficial changes,” more often than with either hormone alone. A landmark article reveals even conservative colleagues are focusing on the endocrine system of healthy patients to produce a healthier, higher quality of life. Review current research and medical articles on energy, productivity and well-being as well as the effects of hormonal modulation, nutrition and lifestyle choices on the matter. Hormones and Sexuality During Transition to Menopause.pdf
This study confirms the observation
that sexual dysfunction increases
over the menopausal transition.
Several factors associated with
sexual dysfunction include low DHEAS,
absence of a sexual partner,
anxiety, and children under the age
of 18 living at home. Fountain of Youth Overflows with Hormones.pdf
According to this article, as baby
boomers age, the fight against aging
is being combated by increased
exercise, better eating habits and
the use of testosterone and other
hormone replenishments.
According to this article,
women may
not be the only ones who suffer the
effects of changing hormones. Some
doctors are noticing that their male
patients are reporting some of the
same symptoms that women experience
in menopause.
This article, which quotes Dr. Alan
Mintz, describes the increased use
of human growth hormone by aging but
relatively healthy people who hope
to improve the quality, and perhaps
the length, of their lives. It
includes discussion for and against
the use of growth hormone. Daily Activity Energy Expenditure and Mortality Among Older Adults.pdf
In this study, objectively measured
free-living activity energy
expenditure was strongly associated
with lower risk of mortality in
healthy older adults. Simply
expending energy through any
activity may influence survival in
older adults.
This study concluded that low muscle
mass did not explain the strong
association of strength with
mortality, demonstrating that muscle
strength as a marker of muscle
quality is more important than
quantity in estimating mortality
risk. Grip strength provided risk
estimates similar to those of
quadriceps strength. Influences of Calorie Restriction and Age on Energy Expenditure in the Rhesus Monkey.pdf
To assess longitudinal effects of CR
on EE in rhesus monkeys (Macaca
mulatta), data from 41 males (M) and
26 females (F) subjected to 9 or 15
yr of CR were studied. EE and body
composition of monkeys 11-28 yr of
age were measured using indirect
calorimetry and dual X-ray
absorptiometry. Total EE (24-h EE)
was divided into daytime (day EE),
nighttime (night EE), and daytime
minus nighttime (D - N EE). Male Menopause Out of the Closet.pdf
According to this article, as men
age, their testosterone levels
gradually decline and some men go
through what is now called male
menopause. But many never get
diagnosed or treated because until
now male menopause has been in the
closet. Endogenous Hormones, Muscle Strength, and Risk of Fall-Related Fractures in Older Women.pdf
This study showed that in
75-year-old women higher serum
estradiol concentration and greater
muscle strength were independently
associated with a low incidence of
fall-related limb fractures even
after adjustment for bone density.
Our results suggest that hormonal
status and muscle strength have
their own separate mechanisms
protecting from fall-related
fractures. This finding is of
importance in developing preventive
strategies, but calls for further
study.
This study concluded that activity
levels in the Yakut were lower than
those in other subsistence groups,
especially the women, and were not
significantly different from those
in persons in industrialized
nations. Persons who participated in
more subsistence activities and
consumed fewer market foods had
significantly higher activity
levels. A Drug’s Promise (or not) of Youth.pdf
The
author of this article says that
growth hormone is the anti-aging
industry’s most potent and
controversial weapon. Some say it
works wonders. Some say it could
shorten your life. Does Growth Hormone Cause Cancer?.pdf
This
study concluded that even if GH/IGF-1
therapy does result in a small
increase in cancer risk compared to
untreated patients with GH
deficiency, it is likely that the
eventual risk will be the same as
the general population. Such a
restoration to normality will need
to be balanced against the known
morbidity of untreated GH
deficiency. Lowering Dietary Glycemic Load for Weight Control and Cardiovascular Health: A Matter of Quality.pdf
This
study concludes that although
significant differences in
neurohormonal responses to different
types of carbohydrates have long
been recognized, until recently this
knowledge has not been
comprehensively and systematically
applied to the study of diet and CVD
in populations or to the development
of food-composition tables in
guiding dietary practice. Prevalence of Hypogonadism in Males Aged at Least 45 Years: The HIM study.pdf
According to this study, based on TT
concentration, the prevalence of
hypogonadism in men reporting to
primary care offices was estimated
to be 38.7%. The medical conditions
that occurred significantly more
frequently among hypogonadal men
than eugonadal men included
increased BMI, hypertension,
hyperlipidaemia, diabetes, and
asthma or COPD. As men age, they are
susceptible to conditions that share
many of the same symptoms similar to
hypogonadism. The presence of these
conditions may, in effect, mask
underlying hypogonadism and
negatively impact quality of life. DHEA in Elderly Women and DHEA or Testosterone in Elderly Men.pdf
This
study concluded that neither DHEA
nor low-dose testosterone
replacement in elderly people has
physiologically relevant beneficial
effects on body composition,
physical performance, insulin
sensitivity, or quality of life.
To
examine hormone levels after
androgen replacement therapy (ART)
in Japanese male patients with
hypogonadism, nine Japanese male
patients with hypogonadism (serum
total testosterone (tT) or free
testosterone (fT) levels of < or =
2.7 ng/mL or < or = 10 pg/mL,
respectively; average age, 59 years)
were enrolled. Hormones May Hold Clues to Healthy Aging.pdf
Two
new studies suggest that specific
hormones may play a key role in
longevity and healthy aging.
Researchers found one hormone,
adiponectin, at higher-than-average
concentrations in 100-year-old
women, while another study found
that stimulating the body's
production of growth hormone brought
a youthful pep back to people in
their 60s to 80s. Low Serum Testosterone and Mortality in Male Veterans.pdf
This
study used a clinical database to
identify men older than 40 years
with repeated testosterone levels
obtained from October 1, 1994 to
December 31, 1999, and without
diagnosed prostate cancer. It
concluded that low testosterone
levels were associated with
increased mortality in male
veterans. Further prospective
studies are needed to examine the
association between low testosterone
levels and mortality. Management of Andropause: The Male Menopause.pdf
According to this article,
andropause is a syndrome of
physical, sexual, and psychological
symptoms in aging men due to a
gradual decline in serum
testosterone levels. Its symptoms
are more prominent in the presence
of concomitant medical disorders.
Testosterone replacement therapy
relieves these symptoms along with
improvement in bone and muscle mass,
sexual function, and quality of
life. Study Links Fat Distribution and Not Body Weight as an Indicator of Cardiovascular Disease Risk.pdf
GE
Healthcare, a unit of General
Electric Company (NYSE: GE),
announced that the company’s Lunar
Prodigy bone density system was used
in a groundbreaking study to
evaluate body composition and fat
distribution in the body as an
important indicator of risk of
cardiovascular disease. The study
was presented at the 27th
Annual Meeting of the American
Society for Bone and Mineral
Research meeting in Nashville, TN,
September 23-27.
Chocolate Does Not Contain Caffeine.pdf
According to this article, there is
a persistent urban legend that
Chocolate contains caffeine. It
would seem that this rumor is based
primarily on a confusion between two
similar alkaloids: Caffeine and
Theobromine. Theobromine is the
active ingredient in Chocolate and
it occurs only in Cacao. The two
stimulants are related and have
similar structures, but are very
different chemicals with different
properties, effects and origins.
There are of course, some Chocolate
products that have added Caffeine,
but it does not occur naturally in
Chocolate.
In
this randomized controlled trial, it
was concluded that for patients with
stable Ischemic Heart Disease (IHD),
exercise and stress management
training reduced emotional distress
and improved markers of
cardiovascular risk more than usual
medical care alone. Experts Consider HT for Younger Women.pdf
Questions still persist after the
release of the July 2002 Women’s
Health
Initiative findings regarding
hormone therapy. Researchers have
been looking at the data to see if
certain changes in dosage or
initiation age could still provide
benefits to women.
This
study was undertaken to determine
the physiological range of these
GH-dependent variables in elite
athletes after a competitive event
to determine whether such values
differ from resting values in normal
and athletic subjects and to
establish whether any adjustments to
this range are required on the basis
of age, gender, demographic
characteristics, or the nature of
the exercise performed. Effects of Estrogen with and without Progestin on Urinary Incontinence.pdf
The
conclusion of this study was that
conjugated equine estrogen alone and
CEE + MPA increased the risk of UI
among continent women and worsened
the characteristics of UI among
symptomatic women after 1 year.
Conjugated equine estrogen with or
without progestin should not be
prescribed for the prevention Male Hormones Could Help Slow Aging in Men, WU Doctor Says.pdf
According to this article, the
natural medical response to
decreasing testosterone in men is to
want to replenish low hormone
levels. Yet no large-scale study has
done for men what the massive
Women's Health Initiative did for
women: Investigate the effects of
replacing important sex hormones in
the aging. But as demographic shifts
bring an increasingly older
population, male hormone replacement
therapy, or HRT, is becoming a
priority. Dehydroepiandrosterone Monotherapy in Midlife-Onset Major and Minor Depression.pdf
This
study found DHEA to be an effective
treatment for midlife-onset major
and minor depression. Hormone Replacement, the Male Version.pdf
According to this article, a growing
number of men in the United States
are now taking testosterone to
reverse the gradual, age-related
decline of the hormone, or so-called
andropause. By some estimates, the
number of testosterone prescriptions
in the United States has tripled in
recent years, and total sales now
come to about $400 million a year.
That’s not much compared with the
$12.5 billion spent on
cholesterol-lowering statins, but
the upward trend is still
impressive.
The
results of this naturalistic study
indicate that chemical castration is
associated with a significant rise
in the plasma levels of Abeta and,
clinically, with increased
depression and anxiety scores. The
discontinuation of treatment is
associated with better cognitive
performance, most noticeably of
verbal memory. The performance of
subjects on the WL test was
negatively correlated with plasma
levels of Abeta, but the clinical
significance of this finding remains
to be determined.
Exogenous Testosterone or
Testosterone with Finasteride
Increases Bone Mineral Density in
Older Men with Low Serum
Testosterone.pdf
In
short-term clinical trials of
androgen replacement in women,
several benefits have been shown,
including improved libido, bone
mineral density and body
composition. While androgen therapy
for women is relatively new, it is
receiving more attention. Formulations and Use of Androgens in Women.pdf
The
use of androgen therapy for
postmenopausal women is discussed in
this article. It suggests that the
goal of androgen treatment should be
to achieve normal premenopausal
levels of testosterone, thus
limiting adverse effects and adverse
experiences.
Insulin-Like Growth Factor-1 as a Vascular Protective Factor.pdf
According to this study, until
recently, IGF-1 was considered a
mediator of vascular disease.
Increasing evidence indicates,
instead, that IGF-1 protects against
endothelial dysfunction,
atherosclerotic plaque development,
the metabolic syndrome, clinical
instability, and ischemic myocardial
damage. Potential Anabolic Effects of Androgens on Bone.pdf
With
the decrease of estrogen at
menopause, the need for androgens
increases in post-menopausal women.
Androgens also appear to be
important for the bone health of
women who are pre-menopausal.
Review by
Amazon.com of Suzanne Somers’
book The Sexy Years: Discover the
Hormone Connection: The Secret to
Fabulous Sex, Great Health, and
Vitality, for Women and Men.
Hot Flashes and Androgens: A Biological Rationale for Clinical Practice.pdf
This
article discusses the important role
androgens play in the treatment of
hot flashes. It also emphasizes the
need to individualize treatment for
menopausal women. Low Androgenization Index in Elderly Women and Elderly Men with Alzheimer's Disease.pdf
The
authors of this study investigated
whether testosterone levels and
testosterone availability differ
between older lean subjects with and
without Alzheimer's disease (AD).
Sex hormone binding globulin (SHBG)
and estradiol levels were higher,
whereas the free androgenization
index (FAI) was lower, in lean
subjects with AD than in lean
subjects without AD. Factors
involved in the increase of SHBG
secretion could have an important
role in the lower testosterone
availability of subjects with AD.
This
study provides further support that
carbohydrate and fat metabolism
influence cardiac outcome and
provides new evidence that dietary
modification prior to coronary
artery bypass surgery can shorten
the hospital stay. Diet Composition and the Risk of Type 2 Diabetes: Epidemiological and Clinical Evidence.pdf
This
article concludes that new emphasis
on prevention by multiple lifestyle
modifications, including moderate
changes in the composition of the
habitual diet, might limit the
dramatic increase in incidence of
type 2 diabetes envisaged worldwide. Risks of Testosterone-Replacement Therapy and Recommendations for Monitoring.pdf
According to this study,
hypogonadism affects an estimated 2
million to 4 million men
in the United States;
its prevalence increases with age.
However, it has been estimated that
only 5 percent of
affected men currently
receive treatment. Recent interest
in
testosterone therapy has been fueled
not only by increased medical
awareness of the
effects of hypogonadism, but also by
media
attention regarding
hormone-replacement therapy in both
men and
women, the marketing of new topical
testosterone formulations,
and the desire of "baby
boomers" to maintain vigor and
health into
their more mature years. The Paradox of the Insulin/IGF-1 Signaling Pathway in Longevity.pdf This review focuses on the downstream cascade of events in the insulin and IGF-1 signaling to identify specific pathways that are relevant to human longevity. Rincon, M., Muzumdar, R., Atzmon, G. & Barzilai, N. (2004). The paradox of the insulin/IGF-1 signaling pathway in longevity [Electronic version]. Mechanisms of Ageing & Development, 125(6), 397-403. Retrieved September 19, 2005.
This
study demonstrates that 1)
improvements in QoL, as measured by
the QLS-H, are maintained during
long-term GH replacement therapy of
adults with GHD, and 2) the QLS-H is
a useful tool for evaluating QoL in
hypopituitary patients treated in
clinical practice. The authors
suggest that evaluation of QoL
should be a part of the routine
clinical management of adult
GH-deficient patients, complementing
the measurement of surrogate
biological markers or other clinical
end points.
This
article concludes that
administration of a low-dose
testosterone to men with COPD for 26
weeks was associated with
improvement of body composition,
better erectile function and sexual
quality of life. Furthermore, there
were no clinical or biochemical side
effects. Nuts, Omega-3s and Food Labels.pdf
According to this letter, arguably,
the most successful secondary
prevention trial for
heart disease was the Lyon
Diet Heart Study, in which the only
intervention was a daily dose of
about 2 tablespoons (about
30 mL) of
unhydrogenated canola oil in the
form of a margarine.
Omega-3 fatty acids are
vitally important, and our new food
labels should indeed
help us to make informed choices.
The
subject of this study was
Dehydroepiandrosterone (DHEA). It
was examined to determine its
effects on the proliferation of
cultured endothelial cells, compare
its effects with those of estradiol
and testosterone, and examine its
effects on subcellular messengers.
Reduced Longevity in Untreated
Patients with Isolated Growth
Hormone Deficiency.pdf
The
results of this study did not reveal
any significant changes in study
parameters, apart from a
statistically significant increase
in DHEA-S levels after therapy with
active substance.
The
results of this study indicated that
a coconut oil-based diet
(HSAFA-diet) lowers postprandial
t-PA antigen concentration, and this
may favorably affect the
fibrinolytic system and the Lp(a)
concentration compared with the
HUFA-diet. The proportions of
dietary saturated fatty acids more
than the percentage of saturated fat
energy seem to have a beneficial
influence on Lp(a) levels.
Endogenous Sex Hormones and
Cardiovascular Disease in Men.pdf
Testosterone surges may be one of
the factors that separate
Oscar-winners like Jack Nicholson
and Al Pacino from aspiring actors
whose careers never get off the
ground, new study findings suggest.
It is
concluded that one year
discontinuation of GH treatment
leads to a decrease in QoL within 6
months which effect is counteracted
within 6 months after restart of GH
treatment.
Dehydroepiandrosterone Augmentation
in the Management of Negative,
Depressive, and Anxiety Symptoms in
Schizophrenia.pdf
This
article cites the article by Rudman
et al. that
appeared in the Journal in
1990 that reported the effect on
body composition of
administering human growth hormone
for six
months to 12 older men. This article
incited a proliferation
of "antiaging" clinics
and lay publications, such as "Grow
Young with
HGH," extolling the benefits of
growth hormone in reversing
or preventing aging.
This
study concluded that in elderly
patients undergoing total hip
replacement, preoperative GH
treatment results in improvements in
lean body mass and skeletal muscle
mass that are sufficient to offset
postoperative losses. The treatment
may also preserve or improve muscle
strength and postoperative walking
ability.
This
study examined the effects of GH
and/or testosterone (T)
administration on body composition,
performance, mood, sexual function,
bone turnover, and muscle-gene
expression in healthy older men. It
concluded that 1 month of GH and/or
T administration improves certain
measures of balance and physical
performance in older men and
increases muscle IGF-I gene
expression.
This
study concludes that recombinant
human growth hormone (rhGH) has a
beneficial effect on metabolism in
patients who are severely burned.
Hyperglycemia, however, is apt to
occur and water, Na(+), Cl(-)
retention are suggested. Fifty
patients were studied.
This
study concluded that 12 months of GH
replacement normalized IGF-I and
improved lipid profile and cardiac
performance in adult GHD patients. A
similar period of GH deprivation
induced a further impairment of
lipid profile and cardiac
performance. This finding strongly
supports the need of GH replacement
in adult GHD patients.
Shouldn't Adults with Growth Hormone Deficiency Be Offered Growth Hormone Replacement Therapy?.pdf
This analysis should encourage
reluctant practitioners to at least
consider growth hormone replacement
therapy for patients with definite
growth hormone deficiency--that is,
patients with symptomatic
panhypopituitarism. The Effects of Tibolone on Mood and Libido.pdf
According to this paper, published
studies indicate beneficial effects
of tibolone on both
libido and mood, which otherwise
significantly compromise physical,
psychological, and social
well-being. Hence, tibolone provides
another option for menopausal women
experiencing loss of libido as part
of their symptomatology or who have
persistent low libido despite
adequate estrogen/progestin
replacement therapy. GH-Deficient Survivors of Childhood Cancer: GH Replacement During Adult Life.pdf
This
article proposes that, as in
patients with hypopituitarism caused
by pituitary disease, the main
indication for GH replacement in
GH-deficient survivors of childhood
cancer should be severe impairment
of quality of life.
This
study demonstrates differential
effects of steroids on GSH levels in
different cellular CNS models,
showing an important influence of
steroids and especially E(2) on
antioxidative cellular functions in
neuronal and glial cells. Exercise Type and Intensity in Relation to Coronary Heart Disease in Men.pdf
This
study concluded that total physical
activity, running, weight training,
and walking were each associated
with reduced CHD risk. Average
exercise intensity was associated
with reduced risk independent of the
number of MET-hours spent in
physical activity.
This
study discusses how low-dose GHR
improves body composition and QoL as
early as 1 month after commencement
and the beneficial effects continue
at 3 months. Most importantly, these
changes occur in the absence of
side-effects. Association of IGF-I Levels with Muscle Strength and Mobility in Older Women.pdf
This
article summarizes that in a study
population including frail and
healthy older women, low IGF-I
levels were associated with poor
knee extensor muscle strength, slow
walking speed, and self-reported
difficulty with mobility tasks.
These findings suggest a role for
IGF-I in disability as well as a
potential target population for
interventions to raise IGF-I levels.
This
article concludes that GH
replacement for 12 months
significantly improved lipid
profile, decreased fibrinogen
levels, and increased LVMi and LVEF
in young adults with co- or ao-GHD.
However, lipid profile, fibrinogen
levels, and systolic function
remained abnormal compared with
those in age- and sex-matched
controls, suggesting that a longer
period of GH replacement is
necessary to normalize
cardiovascular parameters and
reverse the cardiovascular risk of
these patients. What are "Normal" Testosterone Levels for Women?.pdf
In this Letter to
the Editor, the authors conclude
that the role of androgens in women
is becoming increasingly more
recognized and established.
Certainly, the use of androgens,
particularly testosterone, has been
shown to influence life aspects,
such as mood, women’s general well
being and restoration of sexual
desire. However, there is limited
data establishing normal androgen
values for women of differing ages,
to enable us to define those with
"androgen deficiency." They say it
is, therefore, necessary to
highlight the incongruencies and
short-comings of the paper by
Laughlin et al. (Laughlin G,
Barrett-Connor E, Kritz-Silverstein
D, Von Muhlen D. 2000 Hysterectomy,
oophorectomy, and endogenous sex
hormone levels in older women: the
Rancho Bernado Study. J Clin
Endocrinol Metab. 85:645–651), and
the need for larger prospective
studies to establish the variations
in testosterone levels in women with
age. Personal Business; Trying to Roll Back the Biological Clock, for a Price.pdf
This
article, written soon after
September 11th,
says that Americans have been
re-evaluating their priorities since
the attacks, and for some people
that means paying closer attention
to their health. There has even been
a rise in interest in so-called
anti-aging clinics. It discusses
several clinics, including
Cenegenics. Androgen Replacement Therapy in the Aging Male--A Critical Evaluation.pdf
This article concludes that aging
is unavoidable and physiologic, but
the large interindividual disparity
in the pace of development and
progression of signs and symptoms of
aging, suggests that the development
of this symptomatology can be
delayed and that a high quality of
life can be maintained until a very
advanced age, in other words that it
is possible to add life to years.
Being aware of these possibilities,
more and more elderly men (and
women) will seek medical help to
achieve these goals.
This
transcript from Business Unusual
includes responses given by Dr. Alan
Mintz as well as two Cenegenics
patients.
This
study concluded that T gel
replacement improved sexual function
and mood, increased lean mass and
muscle strength (principally in the
legs), and decreased fat mass in
hypogonadal men with less skin
irritation and discontinuation
compared with the recommended dose
of the permeation-enhanced T patch.
This
article states that recent
availability of recombinant human
growth hormone (GH) has led to
intense investigation of the
consequences of adult GH deficiency
(GHD) and the effects of GH
replacement. These studies have led
to the identification of a
characteristic syndrome of GHD
consisting of decreased mood and
well-being, with alterations in body
composition and substrate
metabolism.
Testosterone Replacement Therapy for Anxiety.pdf
In
this Letter to the Editor, the
authors report the case of a patient
with previously
undiagnosed hypogonadism
whose anxiety symptoms improved
after he
received testosterone injections. Testosterone Therapy in Men: An Update.pdf
This
article discusses that because
testosterone levels decline with
age, and aging is accompanied by
body changes including loss of
muscle and increases in fat, there
is great interest in the potential
benefits of testosterone
administration in elderly men.
These
epidemiologic data suggest that a
high dietary glycemic load from
refined carbohydrates increases the
risk of CHD, independent of known
coronary disease risk factors. Testosterone Replacement and the Physiologic Aspects of Aging in Men.pdf
The
focus of the clinical investigations
described here is to determine
whether testosterone deficiency is a
physiologic cause of the aging
process and whether testosterone
replacement might prevent or
ameliorate a decline in quality of
life associated with age-related
decline in physical and
psychological functioning. Experience with Testosterone Replacement in the Elderly.pdf
According to this discussion, to
date, most of the studies of
androgen replacement have been done
with healthy older men (age > or =
55 years), and almost no data are
available for frail elderly
individuals. Treatment effects that
make a relatively small difference
in younger, more robust individuals
may have a greater effect on the
elderly, whose improvement in
functioning and level of activity
may be more dramatic.
This
study concludes that 50 mg DHEA
seems to be a suitable substitution
dose in elderly men, as it leads to
serum DHEAS concentrations usually
measured in young healthy adults.
The DHEA-induced increase in
circulating estrogens may contribute
to beneficial effects of DHEA in
men. Risks Versus Benefits of Testosterone Therapy in Elderly Men.pdf
This
review discusses the pros and cons
of testosterone replacement in
hypogonadal elderly men and attempts
to answer some of the unanswered
questions. Furthermore, emphasis is
made on the regular follow-up of
these patients to prevent the
development of therapy-related
complications.
According to this study, in contrast
to virtually all aspects of
metabolism, QOL is difficult to
measure. Only recently have tests
been developed to assess general
QOL, whereas specific tests address
those aspects of QOL affected only
in specific situations or disease
states. The Effects of 10 Years of Recombinant Human Growth Hormone (GH) in Adult GH-Deficient Patients.pdf
This
study concluded that GH treatment
for 10 yr in GHD adults resulted in
increased lean body and muscle mass,
a less atherogenic lipid profile,
reduced carotid intima media
thickness, and improved
psychological well-being.
This
study concluded that perioperative
hGH treatment of younger patients
undergoing major abdominal surgery
preserved limb lean tissue mass,
increased postoperative muscular
strength, and reduced long-term
postoperative fatigue.
An
intervention study was performed to
evaluate the influence of a
Mediterranean diet, a high fat diet,
and their supplementation with red
wine in moderate amounts, on
biochemical, physiological, and
clinical parameters related to
atherosclerosis and other chronic
diseases. The results presented
support the following conclusions: a
high fat diet induces oxidative
stress; a diet rich in fruits and
vegetables enhances antioxidant
defenses; wine supplementation to a
high fat or a Mediterranean diet
increases plasma antioxidant
capacity, decreases oxidative DNA
damage, and normalizes endothelial
function.
The
present results from this study
indicate a reduction in
pro-thrombotic potential in patients
receiving highly concentrated n-3
FA, whereas some proinflammatory
responses might be adverse. Growth Hormone Therapy in Adults and Children.pdf
According to this study, the goals
of growth hormone therapy in adults
is to restore normal body
composition, improve muscle and
cardiac function, normalize serum
lipid concentrations, and improve
the quality of life. Growth Hormone Deficiency in Adulthood and the Effects of Growth Hormone Replacement: A Review.pdf
The
importance of GH throughout adult
life is now unequivocally accepted.
GH deficiency is
recognized to result in alterations
in body composition,
physical performance,
psychological well-being, and
substrate
metabolism. Many of these
alterations can be improved or
corrected
with GH replacement. The prospect
of GH replacement becoming routine,
however, does raise a number of
issues.
This
study concluded that low free IGF-I
and high IGFBP-1 levels are
associated with a decreased
self-reported quality of health, but
are not related to physical
disability in the elderly. Choice of Cooking Oils--Myths and Realities.pdf
This
article discusses how the newer
"heart-friendly" oils like sunflower
or safflower oils possess
undesirable PUFA content and there
are numerous research data now
available to indicate that the sole
use or excess intake of these newer
vegetable oils are actually
detrimental to health and switching
to a combination of different types
of fats including the traditional
cooking fats like ghee, coconut oil
and mustard oil would actually
reduce the risk of dyslipidaemias,
AHD and Type-2 DM. Postmenopausal Hormone Therapy. Is it Useful for Coronary Prevention?.pdf
This
article states that because about
one of two U.S. women die from
cardiovascular disease (heart
disease and stroke), emphasis is
warranted on available data, which
suggest that the group of women
likely to experience the greatest
cardioprotection from hormone
therapy are those with defined
coronary disease or those at high
risk for occurrence; the group of
women least likely to benefit are
those at increased risk for breast
cancer
Two Years of Replacement Therapy in Adults with Growth Hormone Deficiency.pdf
A
large group of human growth hormone
(hGH) deficient adults received
human growth hormone (hGH)
replacement therapy for two years.
The study confirmed that human
growth hormone (hGH) supplementation
and modulation created beneficial
effects on body composition,
metabolic parameters and improvement
on a general sense of well-being.
This
study concluded that testosterone
replacement therapy appears to be
well tolerated by over 84% of the
subjects. Long term testosterone
replacement to date appears to be a
safe and effective means of treating
hypogonadal elderly males, provided
that frequent follow-up blood tests
and examinations are performed. DHEA: A Biologist's Perspective.pdf
According to the author, it has been
proposed that replacement therapy
with DHEA to restore youthful levels
of DHEAS in older individuals might
have beneficial effects on a variety
of age-related conditions, such as
cardiovascular and neoplastic
diseases, diabetes, immune
dysfunction, muscular weakness, and
depression.
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