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Male Menopause – Andropause Treating the aging male means understanding the symptomology of male menopause. Declines of androgens and related factors must be considered since they affect physical and emotional health. Studies show that merely bolstering testosterone is not necessarily the sole or a simple solution. Review current research and medical articles on male menopause to create a viable protocol for your patients. Prostate Cancer and the Testosterone ‘Myth’.pdf
In this interview,
Abraham Morgentaler,
M.D. concludes his
comments saying that
“testosterone
treatment can be
enormously helpful
for many men.
Attitudes are
shifting with regard
to its relationship
to prostate cancer.”
He references his
article on the
subject that
appeared in
European Urology
in 2006.
This study concluded
that despite blocked
acute responses of
testosterone and 10-
to 20-fold lower
resting levels in
the goserelin group,
ST resulted in a
similar mRNA
expression of myoD,
myogenin, IGF-IE(abc),
myostatin and
androgen receptor as
observed in the
placebo group.
Therefore, in the
present study, the
molecular events
were the same,
despite divergent
muscle hypertrophy
and strength gains. Fountain of Youth Overflows with Hormones.pdf
According to this
article, as baby
boomers age, the
fight against aging
is being combated by
increased exercise,
better eating habits
and the use of
testosterone and
other hormone
replenishments.
According to this
article,
women may not be the
only ones who suffer
the effects of
changing hormones.
Some doctors are
noticing that their
male patients are
reporting some of
the same symptoms
that women
experience in
menopause. Male Menopause Out of the Closet.pdf
According to this
article, as men age,
their testosterone
levels gradually
decline and some men
go through what is
now called male
menopause. But many
never get diagnosed
or treated because
until now male
menopause has been
in the closet. Don’t Call it Male Menopause.pdf
As men start to age,
their bodies also
start to undergo
major changes. They
don't get hot
flashes, but they do
experience hormonal,
physiological and
chemical shifts that
can affect many
aspects of their
lives. This article
suggests that you
can call it aging;
just don't call it
male menopause. Low SHBG, Testosterone, and Clinical AD Are Linked to Metabolic Syndrome Development.pdf
According to this
article, low sex
hormone-binding
globulin, total
testosterone, and
symptomatic androgen
deficiency are
associated with
development of the
metabolic syndrome
in nonobese men.
This study
demonstrated that
aging men with
obesity and the
metabolic syndrome
have a significant
decrease in total
serum testosterone
levels compared to
aging, metabolically
healthy men. These
data suggest that
the well established
association between
erectile dysfunction
and
pre-diabetes/diabetes
(particularly in
obese
pre-diabetic/diabetic
patients) may
involve a hormonal
component.
This study
concluded that serum
TT, SHBG, DHEAS and
ADT levels are
significantly lower
in Arab men compared
to those reported
for Caucasian men,
especially in early
adulthood. Arab men
with newly diagnosed
prostate cancer have
higher circulating
androgens compared
to healthy controls.
We suggest that low
circulating
androgens and their
adrenal precursors
in Arab men when
compared to
Caucasians may
partially account
for the relatively
lower risk for
prostate cancer
among Arab men. Prevalence of Hypogonadism in Males Aged at Least 45 Years: The HIM study.pdf
According to this
study, based on TT
concentration, the
prevalence of
hypogonadism in men
reporting to primary
care offices was
estimated to be
38.7%. The medical
conditions that
occurred
significantly more
frequently among
hypogonadal men than
eugonadal men
included increased
BMI, hypertension,
hyperlipidaemia,
diabetes, and asthma
or COPD. As men age,
they are susceptible
to conditions that
share many of the
same symptoms
similar to
hypogonadism. The
presence of these
conditions may, in
effect, mask
underlying
hypogonadism and
negatively impact
quality of life.
To examine
hormone levels after
androgen replacement
therapy (ART) in
Japanese male
patients with
hypogonadism, nine
Japanese male
patients with
hypogonadism (serum
total testosterone
(tT) or free
testosterone (fT)
levels of < or = 2.7
ng/mL or < or = 10
pg/mL, respectively;
average age, 59
years) were
enrolled. Low Serum Testosterone and Mortality in Male Veterans.pdf
This study used a
clinical database to
identify men older
than 40 years with
repeated
testosterone levels
obtained from
October 1, 1994 to
December 31, 1999,
and without
diagnosed prostate
cancer. It
concluded that low
testosterone levels
were associated with
increased mortality
in male veterans.
Further prospective
studies are needed
to examine the
association between
low testosterone
levels and
mortality. Management of Andropause: The Male Menopause.pdf
According to this
article, andropause
is a syndrome of
physical, sexual,
and psychological
symptoms in aging
men due to a gradual
decline in serum
testosterone levels.
Its symptoms are
more prominent in
the presence of
concomitant medical
disorders.
Testosterone
replacement therapy
relieves these
symptoms along with
improvement in bone
and muscle mass,
sexual function, and
quality of life. Multicenter Study on the Prevalence of Sexual Symptoms in Male Hypo and Hyperthyroid Patients.pdf
This study
concludes that most
patients with
thyroid hormone
disorders experience
some sexual
dysfunctions, which
can be reversed by
normalizing thyroid
hormone levels.
Despite the
associated changes
in sex hormone
levels, the high
prevalence of
ejaculatory
disorders and their
prompt reversibility
suggest a direct
involvement of
thyroid hormones in
the physiology of
ejaculation.
Prostatic Specific Antigen in Patients with Hypogonadism: Effect of Testosterone Replacement.pdf
The current study
demonstrated that
the level of PSA was
not significantly
changed after 1 year
of testosterone
replacement therapy
in patients with
hypogonadism
associated with ED. Male Hormones Could Help Slow Aging in Men, WU Doctor Says.pdf
According to this
article, the natural
medical response to
decreasing
testosterone in men
is to want to
replenish low
hormone levels. Yet
no large-scale study
has done for men
what the massive
Women's Health
Initiative did for
women: Investigate
the effects of
replacing important
sex hormones in the
aging. But as
demographic shifts
bring an
increasingly older
population, male
hormone replacement
therapy, or HRT, is
becoming a priority.
Adrian Dobs, MD,
professor of
endocrinology at the
Johns Hopkins
University School of
Medicine, spoke
about low
testosterone at the
87th
Annual Meeting of
the Endocrine
Society. Dobs said
data from the
Baltimore
Longitudinal Study
of Aging
demonstrated that as
many as 50% of men
between the ages of
70 and 79 may have
hypogonadism. Hormone Replacement, the Male Version.pdf
According to this
article, a growing
number of men in the
United States are
now taking
testosterone to
reverse the gradual,
age-related decline
of the hormone, or
so-called andropause.
By some estimates,
the number of
testosterone
prescriptions in the
United States has
tripled in recent
years, and total
sales now come to
about $400 million a
year. That’s not
much compared with
the $12.5 billion
spent on
cholesterol-lowering
statins, but the
upward trend is
still impressive. Endogenous Sex Hormone Levels and Cognitive Function in Aging Men: Is There an Optimal Level?.pdf
The objective of
this article is to
determine whether
endogenous sex
hormone levels are
associated with
cognitive
functioning in men.
As many as half
of the Viagra
anti-impotence pills
sold on the Internet
could be
counterfeit. With
impotence, or
erectile dysfunction
(ED), affecting
about 152 million
men worldwide, there
is a huge market for
the treatment.
A third of men
with type 2 diabetes
have low
testosterone levels,
a new study
suggests.
Testosterone helps
men reduce body fat
and improves the way
their bodies handle
insulin. So low
testosterone levels
may have serious
consequences for men
with diabetes,
suggests Sandeep
Dhindsa, MD, of
State University of
New York at Buffalo.
Review by
Amazon.com of
Suzanne Somers’ book
The Sexy Years:
Discover the Hormone
Connection: The
Secret to Fabulous
Sex, Great Health,
and Vitality, for
Women and Men.
Low Androgenization Index in Elderly Women and Elderly Men with Alzheimer's Disease.pdf
The authors of
this study
investigated whether
testosterone levels
and testosterone
availability differ
between older lean
subjects with and
without Alzheimer's
disease (AD). Sex
hormone binding
globulin (SHBG) and
estradiol levels
were higher, whereas
the free
androgenization
index (FAI) was
lower, in lean
subjects with AD
than in lean
subjects without AD.
Factors involved in
the increase of SHBG
secretion could have
an important role in
the lower
testosterone
availability of
subjects with AD. Risks of Testosterone-Replacement Therapy and Recommendations for Monitoring.pdf
According to this
study, hypogonadism
affects an estimated
2 million to 4
million men
in the
United States; its
prevalence increases
with age. However,
it has been
estimated that only
5 percent of
affected men
currently receive
treatment. Recent
interest in
testosterone therapy
has been fueled not
only by increased
medical
awareness of the
effects of
hypogonadism, but
also by media
attention regarding
hormone-replacement
therapy in both men
and
women, the marketing
of new topical
testosterone
formulations,
and the
desire of "baby
boomers" to maintain
vigor and health
into
their more mature
years. Age-Related Testosterone Depletion and the Development of Alzheimer Disease.pdf
This study
observed that brain
levels of
testosterone but not
estradiol were
inversely correlated
with age in men aged
50
to 97 years
who were diagnosed
as
neuropathologically
normal.
This article
concludes that
administration of a
low-dose
testosterone to men
with COPD for 26
weeks was associated
with improvement of
body composition,
better erectile
function and sexual
quality of life.
Furthermore, there
were no clinical or
biochemical side
effects. Endogenous Sex Hormones and Cardiovascular Disease in Men.pdf
The purpose of
this article is to
summarize the
evidence currently
available on the
association between
endogenous sex
hormones and
cardiovascular
disease in males.
Published studies
dealing with the
relationship between
circulating levels
of sex hormones and
cardiovascular
disease in males
were reviewed. The
studies reviewed in
this article suggest
that circulating
endogenous sex
hormones and
estrogens have a
neutral or
beneficial effect on
cardiovascular
disease in men. Does Testosterone Boost an Actor's Oscar Odds?.pdf
Testosterone
surges may be one of
the factors that
separate
Oscar-winners like
Jack Nicholson and
Al Pacino from
aspiring actors
whose careers never
get off the ground,
new study findings
suggest. Male Menopause & Chronic Fatigue Syndrome.pdf
This article says
that it might come
as a shock to some,
but men can suffer
from a form of
menopause similar to
what women endure.
In fact this malady,
sometimes called
male menopause,
shares a number of
Chronic Fatigue
Syndrome (CFS)
symptoms. Association Between Prostate Cancer and Serum Testosterone Levels.pdf
The findings of
this study show that
serum total and free
testosterone levels
in patients with
prostate cancer are
altered, supporting
the possibility that
prostate cancer may
inhibit serum
testosterone levels. Personal Business; Trying to Roll Back the Biological Clock, for a Price.pdf
This article,
written soon after
September 11th,
says that Americans
have been
re-evaluating their
priorities since the
attacks, and for
some people that
means paying closer
attention to their
health. There has
even been a rise in
interest in
so-called anti-aging
clinics. It
discusses several
clinics, including
Cenegenics.
Androgen Replacement
Therapy in the Aging
Male--A Critical
Evaluation.pdf
This article
discusses that
because testosterone
levels decline with
age, and aging is
accompanied by body
changes including
loss of muscle and
increases in fat,
there is great
interest in the
potential benefits
of testosterone
administration in
elderly men.
The objective of
this study was to
review the
literature on the
hormonal changes
that occur in aging
males in order to
determine if
testosterone
declines in relation
to depressed mood
and if testosterone
might prove useful
in treatment of
depression.
Testosterone
Replacement and the
Physiologic Aspects
of Aging in Men.pdf
The present study
confirms short-term
data published in
the literature on a
sex difference in
rhGH dose
requirement in
GH-deficient
patients. It
furthers extends the
data by
demonstrating that
this sex difference
in GH responsivity
persists and changes
during the 24 months
of the study.
Moreover, it shows
that estrogen
replacement blunts
the IGF-I response
to rhGH in women,
whereas in men with
androgen
substitution the
responsivity
increases over time,
thus bearing a risk
of undertreatment in
women and
overtreatment in
men.
The data from
this study highlight
the value of large
longitudinal
surveillance
databases in
defining the optimum
dose regimen for GH
replacement and
indicate that women
may need a higher
replacement dose of
GH than men.
The results of
this study do not
support the role of
sex steroid hormones
in CAD. However, the
relationship between
sex steroids and
serum lipids needs
further
clarification. Hormones and Hair Patterning in Men: A Role for Insulin-Like Growth Factor 1?.pdf
Fifty-one men
over age sixty-five
participated in this
study. It concludes
that testosterone,
sex hormone-binding
globulin and IGF-1
may be important in
determining hair
patterning in men. Insulin-Like Growth Factor 1 and Hair Growth.pdf
This article
discusses that
Insulin-like growth
factor 1 (IGF-1) has
been identified as
an important growth
factor in many
biological systems
and how IGF-1 may be
able to stimulate
the proliferation of
hair follicle cells
through cellular
signaling pathways
of its receptors. Growth Hormone Deficiency in Adulthood and the Effects of Growth Hormone Replacement: A Review.pdf
The importance of
GH throughout adult
life is now
unequivocally
accepted.
GH
deficiency is
recognized to result
in alterations in
body composition,
physical
performance,
psychological
well-being, and
substrate
metabolism. Many of
these alterations
can be improved or
corrected
with GH
replacement. The
prospect of GH
replacement becoming
routine, however,
does raise a number
of issues. Two Years of Replacement Therapy in Adults with Growth Hormone Deficiency.pdf
A large group of
human growth hormone
(hGH) deficient
adults received
human growth hormone
(hGH) replacement
therapy for two
years. The study
confirmed that human
growth hormone (hGH)
supplementation and
modulation created
beneficial effects
on body composition,
metabolic parameters
and improvement on a
general sense of
well-being.
This study
concluded that
testosterone
replacement therapy
appears to be well
tolerated by over
84% of the subjects.
Long term
testosterone
replacement to date
appears to be a safe
and effective means
of treating
hypogonadal elderly
males, provided that
frequent follow-up
blood tests and
examinations are
performed.
The finding that
IGF-1 is present in
levels about
one-half as great in
SF as compared with
serum suggests that
IGF-1 may be
produced in lesser
amounts or is
utilized by the
patient in customary
joint function. The
finding that GH is
present in SF at
values twice as
high, or more, of
serum levels in
inflammatory
arthritides suggests
that GH may play a
role in the
pathophysiology of
arthritic disorders.
Adult patients
with human growth
hormone (hGH)
deficiency are
thought to be at a
higher risk of
cardiovascular
disease. This study
concludes that human
growth hormone (hGH)
supplementation and
modulation of adult
human growth hormone
(hGH) deficient
patients is
associated with
beneficial changes
in lipid and
lipoprotein
profiles.
To measure the
effect of
testosterone
replacement and
venesection on
spinal and
peripheral bone
mineral this study
prospectively
examined six
hypogonadal men and
six eugonadal men
with idiopathic
hemochromatosis for
24 months. The data
suggest that bone
mineral increases in
the lumbar spine and
in the forearm in
hypogonadal men with
hemochromatosis
treated by
testosterone
replacement and
venesection.
This study
examined the effect
of iron depletion on
reproductive
function in a
37-yr-old man with
hypogonadotropic
hypogonadism due to
idiopathic
hemochromatosis. It
was concluded that
phlebotomy alone may
be adequate
treatment for
hypogonadotropic
hypogonadism in men
with hemochromatosis.
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