Nutrition

Trans-fats, saturated fats, preservatives, colorings and high-sugar consumption flood the modern diet. Consequently, cholesterol and blood sugar/insulin levels are rising, creating an epidemic for coronary heart disease, strokes, heart attacks, obesity, Type 2 diabetes, metabolic syndrome, hypertension, cancer and gastrointestinal disorders. These conditions can be improved and even avoided with sound nutritional changes. Review current research and medical articles on nutrition as a vital component to healthy aging.


Moderate Consumption of Olive Oil by healthy European Men Reduces Systolic Blood Pressure in Non-Mediterranean Participants.pdf

The results of this study suggest that a moderate consumption of olive oil may be used as an effective tool to reduce SBP of healthy men who do not typically consume a Mediterranean diet. However, additional longer trials are necessary for confirmation.
Bondia-Pons, I., Schroder, H., Covas, M.I., Castellote, A.I., Kaikkonen, J., Poulsen, H.E., et al. (2007). Moderate consumption of olive oil by healthy European men reduces systolic blood pressure in non-Mediterranean participants [Electronic version]. The Journal of Nutrition, 137(1), 84-87. Retrieved May 14, 2007.

Coffee and Cardiovascular Disease: In Vitro, Cellular, Animal, and Human Studies.pdf

In this review, the authors will examine coffee and its bioactives and their connection with and effect on the risk factors which are associated with heart disease such as lipids, blood pressure, inflammation, endothelial function, metabolic syndrome and potentially protective in vivo antioxidant activity. These will be critically examined by means of in vitro studies, cell experiments, animal supplementation, epidemiology, and the most definitive evidence, human trials.
Bonita, J.S., Mandarano, M., Shuta, D. & Vinson, J. (2007). Coffee and cardiovascular disease: In vitro, cellular, animal, and human studies [Electronic version]. Pharmacological Research, 55(3), 187-198. Retrieved May 14, 2007.

Intake of Fish Oil, Oleic Acid, Folic Acid, and Vitamins B-6 and E for 1 Year Decreases Plasma C-Reactive Protein and Reduces Coronary Heart Disease Risk Factors in Male Patients in a Cardiac Rehabilitation Program.pdf

This study concluded that therapeutic lifestyle changes, effected through a CR program comprising regular exercise and the intake of a combination of dietary nutrients, reduced a variety of risk factors in MI patients, which supports the rationale for nutritional programs in the secondary prevention of coronary heart disease.
Carrero, J.J., Fonolla, J., Marti, J.L., Jimenez, J., Boza, J.J. & Lopez-Huertas, E. (2007). Intake of fish oil, oleic acid, folic acid, and vitamins B-6 and E for 1 year decreases plasma C-reactive protein and reduces coronary heart disease risk factors in male patients in a cardiac rehabilitation program [Electronic version].The Journal of Nutrition, 137(2), 384-390. Retrieved May 14, 2007.

Aging, Adiposity, and Calorie Restriction.pdf

This study concluded that calorie restriction in adult men and women causes beneficial metabolic, hormonal, and functional changes, but the precise amount of calorie intake or body fat mass associated with optimal health and maximum longevity in humans is not known. In addition, it is possible that even moderate calorie restriction may be harmful in specific patient populations, such as lean persons who have minimal amounts of body fat.
Fontana, L. & Klein, S. (2007). Aging, adiposity, and calorie restriction [Electronic version]. The Journal of the American Medical Association, 297(9), 986-994. Retrieved May 2, 2007.

Increased Lean Red Meat Intake Does Not Elevate Markers of Oxidative Stress and Inflammation in Humans.pdf

The aim of this study was to determine whether an increase in unprocessed lean red meat intake, partially replacing carbohydrate-rich foods, adversely influences markers of oxidative stress and inflammation. The results of this study suggest that partial replacement of dietary carbohydrate with protein from lean red meat does not elevate oxidative stress or inflammation.
Hodgson, J.M., Ward, N.C., Burke, V., Beilin, L.J. & Puddey, I.B. (2007). Increased lean red meat intake does not elevate markers of oxidative stress and inflammation in humans [Electronic version]. The Journal of Nutrition, 137(2), 363-367. Retrieved May 14, 2007.

Dietary Patterns Throughout Adult Life Are Associated with Body Mass Index, Waist Circumference, Blood Pressure, and Red Cell Folate.pdf – link not working

The objective of this study was to assess the relations between dietary patterns during adult life (at ages 36, 43, and 53 y) and risk factors for chronic disease at age 53 y. Participants of a longitudinal study of health completed a 5-d food diary at 3 occasions during adult life (n = 1265). Factor analysis was used to identify dietary patterns and a pattern score was calculated from the consumption of the food items in each dietary pattern.
McNaughton, S.A., Mishra, G.D., Stephen, A.M. & Wadsworth, M.E. (2007). Dietary patterns throughout adult life are associated with body mass index, waist circumference, blood pressure, and red cell folate [Electronic version]. The Journal of Nutrition, 137(1), 99-105. Retrieved May 14, 2007.

Calcium and Vitamin D Intake and Risk of Colorectal Cancer - The Multiethnic Cohort Study.pdf

The associations of intakes of calcium and vitamin D with colorectal cancer risk were examined in the Multiethnic Cohort Study (Hawaii and Los Angeles, California). In 1993-1996, 85,903 men and 105,108 women aged > or =45 years completed a quantitative food frequency questionnaire. The findings support the hypothesis of protective roles for calcium, vitamin D, and dairy products in the risk of colorectal cancer.
Park, S.Y., Murphy, S.P., Wilkens, L.R., Nomura, A.M., Henderson, B.E. & Kolonel, L.N. (2007). Calcium and vitamin D intake and risk of colorectal cancer - The Multiethnic Cohort Study [Electronic version].  American Journal of Epidemiology, 165(7), 784-793. Retrieved May 14, 2007.

A Combination of Psyllium and Plant Sterols Alters Lipoprotein Metabolism in Hypercholesterolemic Subjects by Modifying the Intravascular Processing of Lipoproteins and Increasing LDL Uptake.pdf

The results of this study indicate that the hypocholesterolemic action of PSY and PS can be explained in part by modifications in the intravascular processing of lipoproteins and by increases in LDL receptor-mediated uptake.
Shrestha. S., Freake, H.C., McGrane, M.M., Volek, J.S. & Fernandez, M.L. (2007). A combination of psyllium and plant sterols alters lipoprotein metabolism in hypercholesterolemic subjects by modifying the intravascular processing of lipoproteins and increasing LDL uptake [Electronic version]. The Journal of Nutrition, 137(5), 1165-1170. Retrieved May 14, 2007.

Fiber Crucial to Breast Health in Premenopausal Women.pdf

According to this article, researchers suggest that fiber may support health in premenopausal women because antioxidant nutrients in high-fiber foods have protective properties against reactive oxygen species. Another theory, they suggested, is that fiber may stabilize insulin levels in the body, since hyperglycemia may be a potential cause of cancer. Another theory why fiber may be important to breast health, they suggested, revolves around estrogen’s role in the development of breast cancer.
VRP Staff. (2007). Fiber crucial to breast health in premenopausal women [Electronic version]. Vitamin Research Products Website. Retrieved May 31, 2007.

Effect of Physical Inactivity on the Oxidation of Saturated and Monounsaturated Dietary Fatty Acids: Results of a Randomized Trial.pdf

This study concluded that independent of changes in energy balance (intake and/or output), physical inactivity decreased the oxidation of saturated but not monounsaturated dietary fat. The effect is apparently not compensated by resistance exercise training. These results suggest that Mediterranean diets should be recommended in sedentary subjects and recumbent patients.
Bergouignan, A., Schoeller, D.A., Normand, S., Gauquelin-Koch, G., Laville, M., Shriver, T., et al. (2006). Effect of physical inactivity on the oxidation of saturated and monounsaturated dietary fatty acids: results of a randomized trial [Electronic version]. PLoS Clinical Trials, 1(5), e27.
Retrieved May 17, 2007.

High Carb, Low Glycemic Index Diet Best to Reduce CV Risk.pdf

Diets high in carbohydrates (CHOs) with low glycemic index (GI) are best for cardiovascular risk reduction, according to the results of a randomized controlled study reported in the July 24 issue of the Archives of Internal Medicine.
Barclay, L. (2006, July 25). High carb, low glycemic index diet best to reduce CV risk [Electronic version]. Medscape Medical News. Retrieved November 14, 2006.

Fruit and Vegetable Juices and Alzheimer's Disease: The Kame Project.pdf

This study concluded that fruit and vegetable juices may play an important role in delaying the onset of Alzheimer's disease, particularly among those who are at high risk for the disease. These results may lead to a new avenue of inquiry in the prevention of Alzheimer's disease.
Dai, Q., Borenstein, A.R., Wu, Y., Jackson, J.C. & Larson, E.B. (2006). Fruit and vegetable juices and Alzheimer's disease: the Kame Project [Electronic version]. The American Journal of Medicine, 119(9), 751-759. Retrieved November 27, 2006.

Debate Flaring up Over Use of Dementia Screening.pdf

According to this article, organizations that issue screening guidelines should consider seriously whether physicians should discuss dementia with patients at age 50 and initiate annual dementia screening in those older than 75. This is according to a perspective piece published in April of 2006 in Alzheimer's & Dementia, the Journal of the Alzheimer's Assn.
Elliott, V.S. (2006, May 15). Debate flaring up over use of dementia screening [Electronic version]. American Medical News, 49(19), 23-24. Retrieved November 16, 2006.

Soy Isoflavones Affect Platelet Thromboxane A2 Receptor Density But Not Plasma Lipids in Menopausal Women.pdf

This study demonstrated that the beneficial effects of isoflavones in menopausal women could be more related to platelet function than to improving classical cardiovascular risk factors.
Garrido, A., De la Maza, M.P., Hirsch, S. & Valladares, L. (2006). Soy isoflavones affect platelet thromboxane A2 receptor density but not plasma lipids in menopausal women [Electronic version]. Maturitas, 54(3), 270-276. Epub January 18, 2006. Retrieved November 27, 2006.

Lowering Dietary Glycemic Load for Weight Control and Cardiovascular Health: A Matter of Quality.pdf

This study concludes that although significant differences in neurohormonal responses to different types of carbohydrates have long been recognized, until recently this knowledge has not been comprehensively and systematically applied to the study of diet and CVD in populations or to the development of food-composition tables in guiding dietary practice.
Liu. S. (2006). Lowering dietary glycemic load for weight control and cardiovascular health: a matter of quality [Electronic version]. Archives of Internal Medicine, 166(14), 1438-1439. Retrieved November 14, 2006.

Validation of Estimates of Total Body Water in Pediatric Dialysis Patients by Deuterium Dilution.pdf

According to this study, current K-DOQI recommendations call for an assessment of dialysis adequacy that depends critically on an estimate of total body water (TBW). Such estimates are problematic in children since the range of patient size is large, and often formulas derived in normals are not validated in end-stage renal disease. Techniques for estimating TBW in pediatric dialysis patients must be validated by independent data sets before being incorporated into clinical and research practice.
Mendley, S.R., Majkowski, N.L. & Schoeller, D.A. (2005). Validation of estimates of total body water in pediatric dialysis patients by deuterium dilution [Electronic version]. Kidney International, 67(5), 2056-2062. Retrieved May 18, 2007.

Sustained Increase in Dietary Oleic Acid Oxidation Following Morning Exercise.pdf

This study concluded that the increase in oleate oxidation when administered after early morning exercise was found to persist for all three meals of the day, with the greatest effect occurring for the lunch meal. Palmitate oxidation, while apparently resistant to the effects of 1250 kJ of prior exercise, increases when administered later in the day, suggesting a diurnal variation in the oxidation of dietary fatty acids. These results demonstrate that prior exercise selectively alters the partitioning of dietary fatty acids. Furthermore, these findings demonstrate additional benefits of substituting monounsaturated for saturated fatty acids in the diet.
Votruba, S.B., Atkinson, R.L. & Schoeller, D.A. (2005). Sustained increase in dietary oleic acid oxidation following morning exercise [Electronic version]. International Journal of Obesity, 29(1), 100-107. Retrieved May 18, 2007.

Obesity, Weight Gain, and Risk of Biochemical Failure Among Prostate Cancer Patients Following Prostatectomy.pdf

The findings of this study validate the importance for a role of obesity in prostate cancer progression and suggest a link to the biological basis of prostate cancer progression that can be therapeutically exploited.
Strom, S.S., Wang, X., Pettaway, C.A., Logothetis, C.J., Yamamura, Y., Do, K, et al. (2005). Obesity, weight gain, and risk of biochemical failure among prostate cancer patients following prostatectomy [Electronic version]. Clinical Cancer Research, 11, 6889-6894. Retrieved October 20, 2005.

Review of the Book The Sexy Years: Discover the Hormone Connection: The Secret to Fabulous Sex, Great Health, and Vitality, for Women and Men.pdf

Review by Amazon.com of Suzanne Somers’ book The Sexy Years: Discover the Hormone Connection: The Secret to Fabulous Sex, Great Health, and Vitality, for Women and Men.
Lightner, J. (2004). [Review of the book The sexy years: Discover the hormone connection: the secret to fabulous sex, great health, and vitality, for women and men]. Retrieved September 10, 2004.

Retrospective Analysis of the Impact of a Low Glycaemic Index Diet on Hospital Stay Following Coronary Artery Bypass Grafting: A Hypothesis.pdf

This study provides further support that carbohydrate and fat metabolism influence cardiac outcome and provides new evidence that dietary modification prior to coronary artery bypass surgery can shorten the hospital stay.
Patel, V.C., Aldridge, R.D., Leeds, A., Dornhorst, A. & Frost G.S. (2004). Retrospective analysis of the impact of a low glycaemic index diet on hospital stay following coronary artery bypass grafting: a hypothesis [Electronic version]. Journal of Human Nutrition & Dietetics, 17(3), 241-247. Retrieved May 17, 2005.

Nuts, Omega-3s and Food Labels.pdf

According to this letter, arguably, the most successful secondary prevention trial for heart disease was the Lyon Diet Heart Study, in which the only intervention was a daily dose of about 2 tablespoons (about 30 mL) of unhydrogenated canola oil in the form of a margarine. Omega-3 fatty acids are vitally important, and our new food labels should indeed help us to make informed choices.
Vos, E. (2004). Nuts, omega-3s and food labels [Electronic version]. Canadian Medical Association Journal, 171(8), 829. Retrieved November 1, 2005.

2001 Uses of Stable Isotopes in the Assessment of Nutrient Status and Metabolism.pdf

Stable isotopes are nonradioactive and can be safely administered to humans; yet, because of the isotopic difference, can be distinguished from the unlabeled moiety and thus trace the nutrient uptake and elimination. Stable isotope applications include measurement of nutrient absorption, determination of nutrient body stores, tracing routes of nutrient metabolism, measuring nutrient fluxes through specific pathways, and measuring nutrient elimination.
Schoeller, D.A. (2003). 2001 uses of stable isotopes in the assessment of nutrient status and metabolism [Electronic version]. Forum of Nutrition, 56, 310-311. Retrieved May 18, 2007.

A Diet Rich in Coconut Oil Reduces Diurnal Postprandial Variations in Circulating Tissue Plasminogen Activator Antigen and Fasting Lipoprotein (a) Compared with a Diet Rich in Unsaturated Fat in Women.pdf

The results of this study indicated that a coconut oil-based diet (HSAFA-diet) lowers postprandial t-PA antigen concentration, and this may favorably affect the fibrinolytic system and the Lp(a) concentration compared with the HUFA-diet. The proportions of dietary saturated fatty acids more than the percentage of saturated fat energy seem to have a beneficial influence on Lp(a) levels.
Muller, H., Lindman, A.S., Blomfeldt, A, Seljeflot, I. & Pedersen, J.I. (2003). A diet rich in coconut oil reduces diurnal postprandial variations in circulating tissue plasminogen activator antigen and fasting lipoprotein (a) compared with a diet rich in unsaturated fat in women [Electronic version]. The Journal of Nutrition, 133(11), 3422-3427. Retrieved November 1, 2005.

Do Omega-3 Fatty Acids Help in Depression?. pdf

This study concluded that despite observational evidence linking depression with reduced intake of long-chain omega-3 fatty acids, there is no convincing basis for using these nutrients as a sole treatment for the condition. There is limited evidence suggesting that long-chain omega-3 fatty acid supplements might help to relieve depression when given in addition to existing antidepressantmedication. However, this needs confirming before they can recommend the routine use of such supplements in patients with depression.
(2000, February). Do omega-3 fatty acids help in depression? [Electronic version]. Drug and Therapeutics Bulletin, 45(2), 9-12. Retrieved May 14, 2007.

Effect of Oral DHEA on Serum Testosterone and Adaptations to Resistance Training in Young Men.pdf

This study examined the effects of acute dehydroepiandrosterone (DHEA) ingestion on serum steroid hormones and the effect of chronic DHEA intake on the adaptations to resistance training. These results suggest that DHEA ingestion does not enhance serum testosterone concentrations or adaptations associated with resistance training in young men.
Brown, G.A., Vukovich, M.D., Sharp, R.L., Reifenrath, T.A., Parsons, K.A., et al. (1999). Effect of oral DHEA on serum testosterone and adaptations to resistance training in young men [Electronic version]. Journal of Applied Physiology, 87(6), 2274-2283. Retrieved September 14, 2005.

Choice of Cooking Oils--Myths and Realities.pdf

This article discusses how the newer "heart-friendly" oils like sunflower or safflower oils possess undesirable PUFA content and there are numerous research data now available to indicate that the sole use or excess intake of these newer vegetable oils are actually detrimental to health and switching to a combination of different types of fats including the traditional cooking fats like ghee, coconut oil and mustard oil would actually reduce the risk of dyslipidaemias, AHD and Type-2 DM.
Sircar, S. & Kansra, U. (1998). Choice of cooking oils--myths and realities [Electronic version]. Journal of the Indian Medical Association, 96(10), 304-307. Retrieved November 1, 2005.