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Skin Appearance & Elasticity Estrogen and the steroidal hormone, testosterone, play a pivotal role in maintaining firm skin. Therefore, hormone optimization may benefit this concern in the aging process, as suggested by various studies. Review current research and medical articles on skin appearance and elasticity to help ameliorate the decline of these age-related issues.
This article, which quotes
Dr. Alan Mintz, describes
the increased use of human
growth hormone by aging but
relatively healthy people
who hope to improve the
quality, and perhaps the
length, of their lives. It
includes discussion for and
against the use of growth
hormone. Experts Consider HT for Younger Women.pdf
Questions still
persist after the
release of the July
2002 Women’s Health
Initiative findings
regarding hormone
therapy.
Researchers have
been looking at the
data to see if
certain changes in
dosage or initiation
age could still
provide benefits to
women.
Male Hormones Could Help Slow Aging in Men, WU Doctor Says.pdf
According to this
article, the natural
medical response to
decreasing
testosterone in men
is to want to
replenish low
hormone levels. Yet
no large-scale study
has done for men
what the massive
Women's Health
Initiative did for
women: Investigate
the effects of
replacing important
sex hormones in the
aging. But as
demographic shifts
bring an
increasingly older
population, male
hormone replacement
therapy, or HRT, is
becoming a priority. Endogenous Sex Hormone Levels and Cognitive Function in Aging Men: Is There an Optimal Level?.pdf
The objective of
this article is to
determine whether
endogenous sex
hormone levels are
associated with
cognitive
functioning in men. Endogenous Sex Hormones and Metabolic Syndrome in Aging Men.pdf
This study
concluded that
higher testosterone
and SHBG levels in
aging males are
independently
associated with a
higher insulin
sensitivity and a
reduced risk of the
metabolic syndrome,
independent of
insulin levels and
body composition
measurements,
suggesting that
these hormones may
protect against the
development of
metabolic syndrome.
Adrian Dobs, MD,
professor of
endocrinology at the
Johns Hopkins
University School of
Medicine, spoke
about low
testosterone at the
87th
Annual Meeting of
the Endocrine
Society. Dobs said
data from the
Baltimore
Longitudinal Study
of Aging
demonstrated that as
many as 50% of men
between the ages of
70 and 79 may have
hypogonadism.
Review by
Amazon.com of
Suzanne Somers’ book
The Sexy Years:
Discover the Hormone
Connection: The
Secret to Fabulous
Sex, Great Health,
and Vitality, for
Women and Men.
Does Testosterone Boost an Actor's Oscar Odds?.pdf
Testosterone
surges may be one of
the factors that
separate
Oscar-winners like
Jack Nicholson and
Al Pacino from
aspiring actors
whose careers never
get off the ground,
new study findings
suggest. Can Growth Hormone Prevent Aging?.pdf
This article
cites the article by
Rudman et al.
that
appeared in the
Journal in 1990
that reported the
effect on
body
composition of
administering human
growth hormone for
six
months to
12 older men. This
article incited a
proliferation
of
"antiaging" clinics
and lay
publications, such
as "Grow Young
with
HGH," extolling the
benefits of growth
hormone in reversing
or
preventing aging. Male Menopause & Chronic Fatigue Syndrome.pdf
This article says
that it might come
as a shock to some,
but men can suffer
from a form of
menopause similar to
what women endure.
In fact this malady,
sometimes called
male menopause,
shares a number of
Chronic Fatigue
Syndrome (CFS)
symptoms.
This study
concludes that
recombinant human
growth hormone
(rhGH) has a
beneficial effect on
metabolism in
patients who are
severely burned.
Hyperglycemia,
however, is apt to
occur and water,
Na(+), Cl(-)
retention are
suggested. Fifty
patients were
studied.
Fifty
severely-burned
patients were
enrolled in this
study, the aim of
which was to explore
the effects of
recombinant human
growth hormone
(rhGH) on the
metabolism of branch
chain amino acid
when applied
postoperatively.
A study involving
seven normotensive,
nondiabetic
GH-deficient adults
(two women)
evaluated skin
capillary
permeability and
capillary density.
It found that the
growth hormone
deficiency syndrome
is associated with
microvascular
alterations, which
are responsive to
growth hormone
replacement. What are "Normal" Testosterone Levels for Women?.pdf
In this Letter to
the Editor, the
authors conclude
that the role of
androgens in women
is becoming
increasingly more
recognized and
established.
Certainly, the use
of androgens,
particularly
testosterone, has
been shown to
influence life
aspects, such as
mood, women’s
general well being
and
restoration
of sexual desire.
However, there is
limited data
establishing normal
androgen values for
women of differing
ages,
to
enable us to define
those with "androgen
deficiency." They
say it
is,
therefore, necessary
to highlight the
incongruencies and
short-comings of the
paper by Laughlin
et al. (Laughlin
G, Barrett-Connor E,
Kritz-Silverstein D,
Von Muhlen D. 2000
Hysterectomy,
oophorectomy, and
endogenous sex
hormone levels in
older women: the
Rancho Bernado
Study. J Clin
Endocrinol Metab.
85:645–651), and the
need
for larger
prospective studies
to establish the
variations in
testosterone levels
in women with age. Hormonal Erectile Dysfunction. Evaluation and Management.pdf
This study showed
that persistent low
testosterone levels
may have significant
detrimental effects
in other organ
systems; therefore,
a timely diagnosis
of androgen
deficiency and
appropriate
treatment may have
significant effects
outside the narrow
field of sexual
performance. Hormonal Effects on Skin Aging.pdf
This article
reviews the effect
of decreasing
hormone levels on
the skin and the
possible benefits of
hormone replacement
therapy (HRT). It
also discusses the
positive effects
Growth Hormone and
estrogen can have on
wound healing. Personal Business; Trying to Roll Back the Biological Clock, for a Price.pdf
This article,
written soon after
September 11th,
says that Americans
have been
re-evaluating their
priorities since the
attacks, and for
some people that
means paying closer
attention to their
health. There has
even been a rise in
interest in
so-called anti-aging
clinics. It
discusses several
clinics, including
Cenegenics. Androgen Replacement Therapy in the Aging Male--A Critical Evaluation.pdf
This article
concludes that aging
is unavoidable and
physiologic, but the
large
interindividual
disparity in the
pace of development
and progression of
signs
and
symptoms of aging,
suggests that the
development of this
symptomatology
can be
delayed and that a
high quality of life
can be maintained
until a
very advanced age,
in other words that
it is possible
to add
life to years. Being
aware of these
possibilities, more
and
more
elderly men (and
women) will seek
medical help to
achieve these
goals.
This study
concludes that DHEA
replacement improves
well-being and
sexuality in women
with adrenal
insufficiency. If
this is due to a
direct effect of
DHEA on the brain,
an indirect effect
via increased
androgen synthesis,
or both, remains to
be elucidated.
Long-term studies in
patients of both
sexes are needed to
further define the
role of DHEA in
standard replacement
for adrenal
insufficiency. Testosterone Supplementation for Erectile Dysfunction: Results of a Meta-Analysis.pdf
In this study,
the meta-analysis of
the usefulness of
androgen replacement
therapy for erectile
dysfunction
indicates that the
response rate for a
primary etiology was
improved over that
for a secondary
etiology,
transdermal
testosterone therapy
was more effective
than intramuscular
or oral treatment,
and intramuscular
and oral treatments
were equivalent. In
addition, there was
a statistically
significant
difference in favor
of testosterone over
placebo, implying a
role for
supplementation in
select groups. Testosterone Therapy in Men: An Update.pdf
This article
discusses that
because testosterone
levels decline with
age, and aging is
accompanied by body
changes including
loss of muscle and
increases in fat,
there is great
interest in the
potential benefits
of testosterone
administration in
elderly men. Testosterone Replacement and the Physiologic Aspects of Aging in Men.pdf
The focus of the
clinical
investigations
described here is to
determine whether
testosterone
deficiency is a
physiologic cause of
the aging process
and whether
testosterone
replacement might
prevent or
ameliorate a decline
in quality of life
associated with
age-related decline
in physical and
psychological
functioning. The Effects of Systemic Hormonal Replacement Therapy on the Skin of Postmenopausal Women.pdf
The aim of this
study was to
determine the
effects of hormonal
replacement therapy
on the skin of
postmenopausal
women. It concluded
that hormonal
replacement for
climacterics
increases skin
collagen content. Dehydroepiandrosterone Replacement in Women with Adrenal Insufficiency.pdf
In a double-blind
study, 24 women with
adrenal
insufficiency
received in random
order 50 mg of
dehydroepiandrosterone
orally each morning
for four months and
placebo daily for
four months, with a
one-month washout
period. The study
concluded that
dehydroepiandrosterone
improves well-being
and sexuality in
women with adrenal
insufficiency. Risks Versus Benefits of Testosterone Therapy in Elderly Men.pdf
This review
discusses the pros
and cons of
testosterone
replacement in
hypogonadal elderly
men and attempts to
answer some of the
unanswered
questions.
Furthermore,
emphasis is made on
the regular
follow-up of these
patients to prevent
the development of
therapy-related
complications. Anabolic Interventions for Age-Associated Sarcopenis.pdf
This commentary
concludes that the
body composition
changes in old age
are multifactorial
and may be related
to the concomitant
changes in hormone
production, protein
turnover, and disuse
atrophy. The
evidence to support
the use of
testosterone or GH
supplementation in
age-related
sarcopenia is only
beginning to be
presented.
From this study
it could be
demonstrated both
clinically and
histologically that
systemic application
of growth hormone
results in a
statistically
significantly more
rapid healing of the
skin graft donor
sites by 2 days
earlier than in the
control group.
Presented is a
modeling study to
provide a possible
explanation for the
observations that
increased exposure
to rhCG induces
higher and then
lower testosterone
concentrations and
that marked rebound
effects are observed
at the end of
repeated
administration of
rhCG. The modeling
results indicate
that when rhCG
concentration
increases, the
testosterone
production rate
increases to 45
times the baseline
value. However, at
an rhCG
concentration of
more than about 30
IU/liter, the
production rate
decreases.
Simulations showed
that both dose and
dosing interval
profoundly influence
testosterone
response to rhCG.
Psychosexual Effects
of Menopause: Role
of Androgens.pdf Hormones and Hair Patterning in Men: A Role for Insulin-Like Growth Factor 1?.pdf
Fifty-one men
over age sixty-five
participated in this
study. It concludes
that testosterone,
sex hormone-binding
globulin and IGF-1
may be important in
determining hair
patterning in men. Insulin-Like Growth Factor 1 and Hair Growth.pdf
This article
discusses that
Insulin-like growth
factor 1 (IGF-1) has
been identified as
an important growth
factor in many
biological systems
and how IGF-1 may be
able to stimulate
the proliferation of
hair follicle cells
through cellular
signaling pathways
of its receptors. Growth Hormone Deficiency in Adulthood and the Effects of Growth Hormone Replacement: A Review.pdf
The importance of
GH throughout adult
life is now
unequivocally
accepted.
GH
deficiency is
recognized to result
in alterations in
body composition,
physical
performance,
psychological
well-being, and
substrate
metabolism. Many of
these alterations
can be improved or
corrected
with GH
replacement. The
prospect of GH
replacement becoming
routine, however,
does raise a number
of issues.
Effect of Exogenous
Testosterone on
Prostate Volume,
Serum and Semen
Prostate Specific
Antigen Levels in
Healthy Young
Men.pdf
The objectives of
this study were to
develop sensitive
assays for the
measurement of the
low total and free
testosterone levels
in women to define
the range for these
hormones during the
normal menstrual
cycle and assess the
total and free
testosterone levels
in HIV-infected
women. No Evidence for Involvement of the Growth Hormone/Insulin-Like Growth Factor-1 Axis in Psoriasis.pdf
Psoriasis
patients took part
in this study to
determine whether
altering the growth
hormone/insulin-like
growth factor-1 axis
plays a role in the
pathogenesis of
psoriasis.
This study
included forty-six
adult men with
childhood-onset of
growth hormone
deficiency.
Twenty-five of the
participants were
androgen-deficient
and received
replacement. The
conclusion of the
study was that for
growth
hormone-deficient
men, growth hormone
substitution therapy
has an auxiliary
effect on androgen
action in the skin
without an increase
of the free androgen
index.
Wrinkling,
dryness and atrophy
were examined in
this study of 3875
postmenopausal
women. The goal of
the study was to
determine the
possible effects
estrogen has on all
three skin
conditions. It was
concluded that the
results strongly
suggest that
estrogen use
prevents dry skin
and wrinkling
associated with
aging. Age-Related Changes in Facial Skin Contours and Rheology.pdf
This article
concludes that aging
of facial skin in
some ways resembles
the features
previously reported
on sun-protected
areas of the
forearms. It also
concludes that HRT
may have a
beneficial effect on
slowing the overall
aging process
without limiting the
number and depth of
wrinkles.
Non-invasive
techniques were used
to study the skin
properties of
postmenopausal
women. The study
included women using
hormone replacement
therapy (HRT) and
and some who were
not being treated
with HRT. It
concluded that the
women who were
receiving HRT had
greater skin
thickness and causal
level than the
untreated women.
The purpose of
this study was to
prove whether
stimulating collagen
type I synthesis
would be accompanied
by a deposition of
collagen type I in
the skin. It
examined twenty
growth
hormone-deficient
hypopituitary
patients for twelve
months. Effect of Hormone Replacement Therapy for Menopause on the Mechanical Properties of Skin.pdf
This study of 114
healthy women,
including
non-menopausal and
menopausal with and
without HRT,
evaluated the effect
of hormone
replacement therapy
for menopause on the
mechanical
properties of the
skin. It concluded
beneficial effects
on some of the
properties. Skin Water-Holding Capacity and Transdermal Estrogen Therapy for Menopause: A Pilot Study.pdf
This study
included two groups
of fifteen
menopausal women.
The purpose was to
model and measure
the influence of
estrogen-transdermal
HRT on subtle
physiological
changes taking place
in the epidermis
during
perimenopause.
This twelve-month
study examines the
possible increase in
skin thickness in
postmenopausal women
as a result of being
treated with
conjugated
estrogens. The
results of the study
may be beneficial to
women who are
looking for
information
regarding the
benefits of estrogen
replacement therapy.
This study
examined endocrine
functions at
baseline and after
TRH and LHRH
stimulation in a
group of 7 young
male patients with
genetic
hemochromatosis (HE)
without liver damage
(i.e. fibrosis and
cirrhosis). In five
patients endocrine
re-evaluations after
complete iron
depletion was also
performed. Long-Term Growth Hormone Treatment in Growth Hormone Deficient Adults.pdf
Overall healthy
aging adults with a
human growth hormone
(hGH) deficiency
were treated over a
lengthy period of
time with human
growth hormone (hGH)
replacement
therapy. The data
suggested that
long-term human
growth hormone (hGH)
supplementation and
modulation in growth
hormone deficient
adults had positive
physiological
effects on features
that are often below
normal in these
patients. The
positive changes
included an increase
in mean muscle
volume, strength,
and exercise
capacity, and
decreased body fat.
Effects of Androgen Treatment in Impotent Men with Normal and Low Levels of Free Testosterone.pdf
The results of
this study suggest
the presence of a
minimum serum fT
threshold, lying
near the lower
normal range, which
determines the male
sexual function.
Moreover, serum fT
levels were a more
sensitive index than
tT for identifying
impotent men who can
be successfully
treated with
androgens.
The results of
this study
demonstrate that the
response to Nal-Glu
in healthy elderly
men is similar to
that in younger men,
and extended
administration of
Nal-Glu in elderly
men effectively
suppresses gonadal
and pituitary
function. These
results suggest that
the role of GnRH
antagonists in the
effective treatment
of
androgen-dependent
disease in the aging
male needs to be
explored further.
To test the
hypothesis that
deficiencies in
hypothalamic-pituitary
function in genetic
hemochromatosis
result from cellular
injury by iron
deposits, this study
conducted
provocative tests in
11 men with genetic
hemochromatosis
before and after
iron depletion by
serial phlebotomy
and in 10 control
subjects. The study
concluded that
abnormal
hypothalamic-pituitary
function in genetic
hemochromatosis is
not substantially
improved by
iron-depletion
therapy.
This study
examined the effect
of iron depletion on
reproductive
function in a
37-yr-old man with
hypogonadotropic
hypogonadism due to
idiopathic
hemochromatosis. It
was concluded that
phlebotomy alone may
be adequate
treatment for
hypogonadotropic
hypogonadism in men
with
hemochromatosis. Testosterone Therapy for Low Sexual Interest and Erectile Dysfunction in Men: A Controlled Study.pdf
The results of
this study support
previous findings
from hypogonadal men
that testosterone
influences sexual
interest but not
erectile function,
and indicate that
increasing plasma
testosterone can
effect sexual
interest even in men
with pre-treatment
testosterone levels
within the normal
range.
Sex Hormones and
Skin Collagen
Content in
Postmenopausal
Women.pdf
The data from
this study and
previous findings
lead to the
conclusion that the
major androgen
action on male
sexuality involves
libido factors (i.e.
sexual
motivation/interest).
Though
stimulus-bound
erections elicited
in the laboratory
were not reduced in
hypogonadal men,
spontaneous (sleep
or waking) erections
were clearly
testosterone
dependent.
The effects of
androgen withdrawal
and replacement were
investigated in six
hypergonadotrophic
and six
hypogonadotrophic
men with
hypogonadism. There
was a significant
fall in sex hormone
binding globulin, a
rise in oestradiol
and no significant
change in
gonadotrophin
concentrations
during T.U.
administration. Gonadal Steroids: Effects on Excitability of Hippocampal Pyramidal Cells.pdf
Electrophysiological
field potentials
from hippocampal
slices of rat brain
show sex-linked
differences in
response to 1 X
10(-10)M
concentrations of
estradiol and
testosterone added
to the incubation
medium. Slices from
male rats show
increased
excitability to
estradiol and not to
testosterone. Slices
from female rats are
not affected by
estradiol, but
slices from female
rats in diestrus
show increased
excitability in
response to
testosterone whereas
slices from females
in proestrus show
decreased
excitability.
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