Vitamin Supplements

Intensely debated, nutraceutical supplementation has undergone examination. The demonstrated efficacy of pharmaceutical-quality supplementation demands our attention—yet, we must alert patients to Internet ads, which lead users into false beliefs. Review current research and medical articles on vitamin supplements and related issues to design an evidence-based protocol for your patients.


Moderate Consumption of Olive Oil by healthy European Men Reduces Systolic Blood Pressure in Non-Mediterranean Participants.pdf

The results of this study suggest that a moderate consumption of olive oil may be used as an effective tool to reduce SBP of healthy men who do not typically consume a Mediterranean diet. However, additional longer trials are necessary for confirmation.
Bondia-Pons, I., Schroder, H., Covas, M.I., Castellote, A.I., Kaikkonen, J., Poulsen, H.E., et al. (2007). Moderate consumption of olive oil by healthy European men reduces systolic blood pressure in non-Mediterranean participants [Electronic version]. The Journal of Nutrition, 137(1), 84-87. Retrieved May 14, 2007.

Intake of Fish Oil, Oleic Acid, Folic Acid, and Vitamins B-6 and E for 1 Year Decreases Plasma C-Reactive Protein and Reduces Coronary Heart Disease Risk Factors in Male Patients in a Cardiac Rehabilitation Program.pdf

This study concluded that therapeutic lifestyle changes, effected through a CR program comprising regular exercise and the intake of a combination of dietary nutrients, reduced a variety of risk factors in MI patients, which supports the rationale for nutritional programs in the secondary prevention of coronary heart disease.
Carrero, J.J., Fonolla, J., Marti, J.L., Jimenez, J., Boza, J.J. & Lopez-Huertas, E. (2007). Intake of fish oil, oleic acid, folic acid, and vitamins B-6 and E for 1 year decreases plasma C-reactive protein and reduces coronary heart disease risk factors in male patients in a cardiac rehabilitation program [Electronic version].The Journal of Nutrition, 137(2), 384-390. Retrieved May 14, 2007.

Lowering Homocysteine with B Vitamins Has No Effect on Blood Pressure in Older Adults.pdf

This study concluded that systolic and diastolic blood pressures as well as pulse pressure in the Vitamins group did not differ from the Placebo group over the duration of the trial. The mean differences in blood pressures, adjusted for baseline values, did not exceed 1 mm Hg. Supplemental B-vitamins lowered plasma homocysteine but had no effect on blood pressure in older people with elevated baseline homocysteine concentrations.
McMahon, J.A., Skeaff, C.M., Williams, S.M. & Green, T.J. (2007). Lowering homocysteine with B vitamins has no effect on blood pressure in older adults [Electronic version]. The Journal of Nutrition, 137(5), 1183-1187. Retrieved May 14, 2007.

Calcium and Vitamin D Intake and Risk of Colorectal Cancer - The Multiethnic Cohort Study.pdf

The associations of intakes of calcium and vitamin D with colorectal cancer risk were examined in the Multiethnic Cohort Study (Hawaii and Los Angeles, California). In 1993-1996, 85,903 men and 105,108 women aged > or =45 years completed a quantitative food frequency questionnaire. The findings support the hypothesis of protective roles for calcium, vitamin D, and dairy products in the risk of colorectal cancer.
Park, S.Y., Murphy, S.P., Wilkens, L.R., Nomura, A.M., Henderson, B.E. & Kolonel, L.N. (2007). Calcium and vitamin D intake and risk of colorectal cancer - The Multiethnic Cohort Study [Electronic version].  American Journal of Epidemiology, 165(7), 784-793. Retrieved May 14, 2007.

Vitamin E Supplementation Raised Chances of New Cancer in at-Risk Patients.pdf

Researchers have reported that cancer patients who took high-dose vitamin E supplements to protect themselves from a recurrence of the disease were actually at higher risk of getting a second cancer while taking the supplement than those in a placebo group.
Vitamin E supplementation raised chances of new cancer in at-risk patients. (2005). [Electronic version]. Nutraingredientsusa.com. Retrieved May 17, 2005.

Homocysteine and Folate as Risk Factors for Dementia and Alzheimer Disease.pdf

The conclusion of this study was that elevated plasma tHcy concentrations and low serum folate concentrations are independent predictors of the development of dementia and AD.
Ravaglia, G., Forti, P., Maioli, F., Martelli, M., Servadei, L., Brunetti, N., et al. (2005). Homocysteine and folate as risk factors for dementia and Alzheimer disease [Electronic version]. The American Journal of Clinical Nutrition, 82(3), 636-643. Retrieved October 31, 2005.

High Homocysteine and Low B Vitamins Predict Cognitive Decline in Aging Men: The Veterans Affairs Normative Aging Study.pdf

This study concluded that low B vitamin and high homocysteine concentrations predict cognitive decline. Spatial copying measures appear to be most sensitive to these effects in a general population of aging men.
Tucker, K.L., Qiao, N., Scott, T., Rosenberg, I. & Spiro, A., 3rd. (2005). High homocysteine and low B vitamins predict cognitive decline in aging men: the Veterans Affairs Normative Aging Study [Electronic version]. The American Journal of Clinical Nutrition, 82(3), 627-635. Retrieved October 31, 2005.

Effect of Simvastatin on Serum C-Reactive Protein During Hormone Replacement Therapy.pdf

In this study it was found that only HRT significantly increased CRP compared with placebo, whereas the combination of HRT with simvastatin did not. It was concluded that statins may reduce the inflammatory adverse effects associated with the CRP increase induced by HRT.
Sbarouni, E., Kyriakides, Z.S. & Kremastinos, D.T. (2004). Effect of simvastatin on serum C-reactive protein during hormone replacement therapy [Electronic version]. The American Journal of Cardiology, 93(2), 217-218. Retrieved September 27, 2005.

Reduced Risk of Alzheimer Disease in Users of Antioxidant Vitamin Supplements.pdf

This study concludes that use of vitamin E and vitamin C supplements in combination is associated with reduced prevalence and incidence of AD. Antioxidant supplements merit further study as agents for the primary prevention of AD.
Zandi, P.P., Anthony, J.C., Khachaturian, A.S., Stone, S.V., Gustafson, D., et al. (2004). Reduced risk of Alzheimer disease in users of antioxidant vitamin supplements [Electronic version].  Archives of Neurology, 61(1), 82-88. Retrieved September 27, 2005.

Hormone Replacement Therapy in Rheumatoid Arthritis is Associated with Lower Serum Levels of Soluble IL-6 Receptor and Higher Insulin-Like Growth Factor 1.pdf

The aim of this study was to investigate the effects of HRT on the serum levels of hormones and cytokines regulating bone turnover in 88 postmenopausal women with active rheumatoid arthritis (RA) randomly allocated to receive HRT plus calcium and vitamin D3 or calcium and vitamin D3 alone for 2 years.
D'Elia, H.F., Mattsson, L.A., Ohlsson, C., Nordborg, E. & Carlsten, H. (2003). Hormone replacement therapy in rheumatoid arthritis is associated with lower serum levels of soluble IL-6 receptor and higher insulin-like growth factor 1 [Electronic version]. Arthritis Research & Therapy, 5(4), R202-209. Epub 2003, May 1. Retrieved October 25, 2005. 

Inappropriate Advertising of Dietary Supplements.pdf

According to this article, recently, a number of advertisements on the Internet have contained statements about dietary supplements that could lead one to believe, erroneously, that information published in the Journal supported the claims made by the manufacturers.
Drazen, J.M. (2003). Inappropriate advertising of dietary supplements [Electronic version]. The New England Journal of Medicine, 348(9), 777-778. Retrieved October 31, 2005.

Growth Hormone Increases Bone Mineral Content in Postmenopausal Osteoporosis: A Randomized Placebo-Controlled Trial.pdf

This study concluded that bone mineral content increased to 14% with GH treatment on top of HRT and calcium/vitamin D in postmenopausal women with osteoporosis. There seems to be a delayed, extended, and dose-dependent effect of GH on bone. Thus, GH could be used as an anabolic agent in osteoporosis.
Landin-Wilhelmsen, K., Nilsson, A., Bosaeus, I. & Bengtsson, B.A. (2003). Growth hormone increases bone mineral content in postmenopausal osteoporosis: a randomized placebo-controlled trial [Electronic version]. Journal of Bone Mineral Research, 18(3), 393-405. Retrieved December 7, 2005.

Personal Business; Trying to Roll Back the Biological Clock, for a Price.pdf

This article, written soon after September 11th, says that Americans have been re-evaluating their priorities since the attacks, and for some people that means paying closer attention to their health. There has even been a rise in interest in so-called anti-aging clinics.  It discusses several clinics, including Cenegenics.
Siwolop, S. (2001, October 21). Personal business; trying to roll back the biological clock, for a price [Electronic version]. The New York Times. Retrieved October 31, 2005.

Do Omega-3 Fatty Acids Help in Depression?. pdf

This study concluded that despite observational evidence linking depression with reduced intake of long-chain omega-3 fatty acids, there is no convincing basis for using these nutrients as a sole treatment for the condition. There is limited evidence suggesting that long-chain omega-3 fatty acid supplements might help to relieve depression when given in addition to existing antidepressantmedication. However, this needs confirming before they can recommend the routine use of such supplements in patients with depression.
(2000, February). Do omega-3 fatty acids help in depression? [Electronic version]. Drug and Therapeutics Bulletin, 45(2), 9-12. Retrieved May 14, 2007.