References:
1. Soules M et al.
Executive summary: Stages of Reproductive Aging Workshop
(STRAW) Menopause: The Journal of The North American
Menopause Society, July 2001. Vol. 8, No. 6, pp. 402–407
2.
North American Menopause Society. Menopause Practice:
A Clinician’s Guide. Cleveland, OH: The North
American Menopause Society; 2004.
3.
Thurston R et al. Adiposity and Reporting of Vasomotor
Symptions among Midlife Women. American Journal of
Epidemiology 2007; 167 (1): 78-85.
4.
Deecher DC. Physiology of Thermoregulatory dysfunction
and current approaches to the treatment of vasomotor
symptoms. Expert Opinion Investigating Drugs 2005; 14:
435-448.
5.
Zoler M. Nonhormonal Drug Eases Vasomotor Symptoms.
Family Practice News 2007; 37 (14): 26-27.
6.
Management Of Vasomotor Symptoms During The Menopausal
Transition. Supplement to Journal of Family Practice
2008; Jan S10
7.
Woods NF, Mitchell ES, Landis C. Anxiety, hormonal
changes, and vasomotor symptoms during the menopause
transition. Menopause. 2005 May-Jun;12(3):242-5
8.
Freeman EW, Sammel MD, Lin H, Gracia CR, Kapoor S,
Ferdousi T. The role of anxiety and hormonal changes in
menopausal hot flashes. Menopause. 12(3):258-266,
May/June 2005.
9.
Davis S, Tran J. What are "normal" testosterone levels
for women? J Clin Endocrinol Metab. 2001
Apr;86(4):1842-4.
10.
National Institutes of Health Osteoporosis and Related
Bone Diseases National Resource Center.
Osteoporosis Overview. Accessed via
http://www.osteo.org/
Cauley
JA, Robbins J, Chen Z, Cummings SR, Jackson RD, LaCroix
AZ, LeBoff M, Lewis CE, McGowan J, Neuner J, Pettinger
M, Stefanick ML, Wactawski-Wende J, Watts NB; Women's
Health Initiative Investigators. Effects of estrogen
plus progestin on risk of fracture and bone mineral
density: the Women's Health Initiative randomized trial.
JAMA. 2003 Oct 1;290(13):1729-38.
11.
Grodstein F et al. Hormone Therapy and Coronary Heart
Disease: The Role of Time Since Menopause and Age at
Hormone Initiation. Journal of Womens Health 2006;
15(1): 35-38
12.
Rossouw J et al. Postmenopausal Hormone Therapy and
Risk of Cardiovascular Disease by Age and Years Since
Menopause. American Medical Association 2007; 297 (13):
1465-1477.
13.
Freedman R et al. Sleep Disturbance in Menopause.
Menopause 2007 May; 14(5): 826-829.
14.
Mold J et al. Associations Between Subjective Night
Sweats and Sleep Study Findings. JABFM 2008 April;
21(2): 96-103
16.
Hsia
J.
Estrogen plus progestin and the risk of peripheral
arterial disease: the Women's Health Initiative.
Circulation. 2004 Feb 10;109 (5):620-6.
17. Mendelsohn ME, Karas RH. The Protective Effects of
Estrogen on the Cardiovascular System. New England
Journal of Medicine 1999; 340: 1801-11.
18.
Grodstein F et al. Postmenopausal Hormone Therapy and
Stroke. American Medical Association 2008 April;
168(8):861-66.
19.
Viscoli CM, Brass LM, Kernan WN, Sarrel PM, Suissa S,
Horwitz RI. A clinical trial of
estrogen-replacement therapy after ischemic stroke. N
Engl J Med. 2001 Oct 25;345(17):1243-9.
20.
Hogervorst E, Williams J, Combrinck M, David Smith A.
Measuring serum oestradiol in women with Alzheimer's
disease: the importance of the sensitivity of the assay
method. Eur J Endocrinol. 2003 Jan;148(1):67-72.
21.
Waring SC, Rocca WA, Petersen RC, O'Brien PC, Tangalos
EG, Kokmen E. Postmenopausal estrogen replacement
therapy and risk of AD: a population-based study.
Neurology. 1999 Mar 23;52(5):965-70.
22.
Shlipak MG. Lipid changes on hormone therapy and
coronary heart disease events in the Heart and
Estrogen/progestin Replacement Study (HERS). American
Heart Journal. Volume 146, Number 5, November 2003.
Copyright © 2003 Mosby, Inc.
23.
Wenger NK,
Weber MA, Scheidt S.
Coronary risk attributes, coronary risk reduction, and
clinical outcomes. Am J Geriatr Cardiol. 2006
May-Jun;15(3):140-1.
24.
Budoff MJ,
Chen GP,
Hunter CJ,
Takasu J,
Agrawal N,
Sorochinsky B,
Mao S.
Effects of hormone replacement on progression of
coronary calcium as measured by electron beam
tomography.
Eur J Obstet Gynecol
Reprod Biol. 2005 Feb 1;118(2):225-8.
25.
Humphries KH. Risks and benefits of hormone replacement
therapy: The evidence speaks. Canadian Medical
Association Journal. Volume 168, Number 8, April 15,
2003. Copyright © 2003 Canadian Medical Association.
26.
Ouyang P, Michos ED, Karas RH. Hormone replacement
therapy and the cardiovascular system lessons learned
and unanswered questions. J Am Coll Cardiol. 2006 May
2;47(9):1741-53. Epub 2006 Apr 17. Review.
27.
Postmenopausal Hormone Therapy and Stroke: Role of Time
Since Menopause and Age at Initiation of Hormone
Therapy. Arch Intern Med. 2008;168(8):861-866.
28.
Crandall C, Palla S, Reboussin BA, Ursin G, Greendale
GA. Positive association between mammographic
breast density and bone mineral density in the
Postmenopausal Estrogen/Progestin Interventions Study.
Breast Cancer Res. 2005;7(6):R922-8. Epub 2005 Sep 22.
30. Popp AW, Bodmer C, Senn C, Fuchs G, Kraenzlin ME,
Wyss H, Birkhaeuser MH, Lippuner K. Prevention of
postmenopausal bone loss with long-cycle hormone
replacement therapy.
Maturitas. 2006 Jan 20;53(2):191-200.
31.
Grady D
Hormone replacement therapy and endometrial cancer risk:
a meta-analysis. - Obstet Gynecol -
01-FEB-1995; 85(2): 304-13
32.
Yang CH,
Lee JN,
Hsu SC,
Kuo CH,
Tsai EM;
Effect of hormone replacement therapy on uterine
fibroids in postmenopausal women--a 3-year study.
Maturitas.
2002 Sep 30;43(1):35-9.
33. Sellers T.A., Mink P.J., Cerhan J.R., Zheng W.,
Anderson K.E., Kushi L.H., Folsom AR. The role of
hormone replacement therapy in the risk for breast
cancer and total mortality in women with a family
history of breast cancer. Ann Intern Med. 1997 Dec
1;127(11):973-80
34.
Willis DB, Calle EE, Miracle-McMahill HL, Heath CW Jr.
Estrogen replacement therapy and risk of fatal breast
cancer in a prospective cohort of postmenopausal women
in the United States. Cancer Causes Control. 1996
Jul;7(4):449-57
35.
Daling JR,
Relation of regimens of combined hormone replacement
therapy to lobular, ductal, and other histologic types
of breast carcinoma.
Cancer,
Volume 95, Issue 12
, Pages 2455 – 2464
36.
Pappo I,
Meirshon I, Karni T, Siegelmann-Danielli N, Stahl-Kent
V, Sandbank J, Wasserman I, Halevy A. The
characteristics of malignant breast tumors in hormone
replacement therapy users versus nonusers.
Ann Surg Oncol.
2004 Jan;11(1):52-8.
37. Collins JA.
Current use of estrogen/progestin increased breast
cancer risk in postmenopausal women more than estrogen
alone
Evidence-based Obstetrics & Gynecology,
Volume 5, Number 4, December 2003. Copyright © 2003
Churchill Livingstone, Inc.
38. Chen WY, Manson JE, Hankinson SE, Rosner B, Holmes MD,
Willett WC, Colditz GA. Unopposed Estrogen Therapy and
the Risk of Invasive Breast Cancer,
Archives of Internal Medicine
2006;166:1027-1032.
39. Creasman
WT, Hoel D, Disaia PJ. WHI: Now that the dust has
settled. Am J Obstet Gynecol. 2003 Sep;189(3):621-6.
Review.
40.
Cengiz B,
Atabekoglu C,
Cetinkaya E,
Cengiz SD;
Effect of hormone replacement therapy on serum levels of
tumor markers in healthy postmenopausal women.
Maturitas.
2003 Dec 10;46(4):301-6
41.
Tang YP,
Haslam SZ,
Conrad SE,
Sisk CL.
Estrogen increases brain expression of the mRNA encoding
transthyretin, an amyloid beta scavenger protein.
J Alzheimers Dis.
2004 Aug;6(4):413-20; discussion 443-9.
42.
Ho KK,
O'Sullivan AJ, Wolthers T, Leung KC. Metabolic effects
of oestrogens: impact of the route of administration.
Ann Endocrinol (Paris). 2003 Apr;64(2):170-7. Review.
43. Janssen
Janssen YJ, Helmerhorst F, Frolich M, Roelfsema F.A
switch from oral (2 mg/day) to transdermal (50 microg/day)
17beta-estradiol therapy increases serum insulin-like
growth factor-I levels in recombinant human growth
hormone (GH)-substituted women with GH deficiency. J
Clin Endocrinol Metab. 2000 Jan;85(1):464-7.
44.
Stevenson JC, Oladipo A, Manassiev N, Whitehead MI,
Guilford S, Proudler AJ.. Randomized trial of effect of
transdermal continuous combined hormone replacement
therapy on cardiovascular risk markers. Br J Hematol.
2004 March;124(6):836-40.
45. Savvas M. Skeletal effects of oral oestrogen compared
with subcutaneous oestrogen and testosterone in
postmenopausal women. BMJ. 1988 Jul 30;297(6644):331-3
46. Watts NB, Notelovitz M, Timmons MC, Addison WA, Wiita
B, Downey LJ. Comparison of oral estrogens and estrogens
plus androgen on bone mineral density, menopausal
symptoms, and lipid-lipoprotein profiles in surgical
menopause. Obstet Gynecol. 1995 Apr; 85(4):529-37.
Erratum in: Obstet Gynecol 1995 May; 85(5 Pt 1):668.
47. Fournier A, Berrino F,
Riboli E,
Avenel V,
Clavel-Chapelon
F.
Breast
cancer risk in relation to different types of hormone
replacement therapy in the E3N-EPIC cohort.
Int J Cancer.
2005 Apr 10;114(3):448-54
48.
de Lignieres B,
de Vathaire F,
Fournier S,
Urbinelli R,
Allaert F,
Le MG,
Kuttenn F.
Combined hormone replacement therapy and risk of breast
cancer in a French cohort study of 3175 women.
Climacteric.
2002 Dec;5(4):332-40.
49. Staren E, Omer S. Hormone replacement therapy in
postmenopausal women. Am J Surg 2004;188(2):136-49
Review
50.
Di Spiezio, S A,
Radhakrishnan S.
Endometrial carcinoma on continuous combined HRT: case
report and literature review.
Maturitas.
2004 Jun 15;48(2):171-5.
51.
Stevenson JC et al. Randomized trial of effect of
transdermal continuous combination hormone replacement
therapy on cardiovascular risk markers. Br J Hematol
2004 March;124(6):836-40.
52. Shoupe D HRT dosing regimens:Continuous versus
Cyclic—Pros and Cons
Int J Fertil 2001;46(1):7-15
53. Stahlberg C, Pedersen AT, Lynge E, Andersen ZJ, Keiding
N, Hundrup YA, Obel EB, Ottesen B.
Increased risk of breast cancer following different
regimens of hormone replacement therapy frequently used
in Europe. Int J Cancer. 2004 May 1;109(5):721-7.
54.
Sarrel PM.,
Sexuality and menopause.
Obstet Gynecol.
1990 Apr;75(4 Suppl):26S-30S
55.. Gelfand, MM. It might be wise to consider adding
androgen to the estrogen or estrogen-progestin regimens
in the appropriate patients. Menopause. 2004
Sep-Oct;11(5):505-7.
56. Davis S, Tran J. What are "normal" testosterone levels
for women? J Clin Endocrinol Metab. 2001
Apr;86(4):1842-4.
57. Miller, K, et al.
Effects of testosterone
replacement in androgen-deficient women with
hypopituitarism: a randomized, double-blind,
placebo-controlled study.
The Journal of Clinical Endocrinology & Metabolism
2006; 91:1683-1690.
58.. Paoletti AM, Congia S, Lello S, Tedde D, Orru M,
Pistis M, Pilloni M, Zedda P, Loddo A, Melis GB. Low
androgenization index in elderly women and elderly men
with Alzheimer's disease. Neurology. 2004 Jan
27;62(2):301-3.
59.
Hogervorst E, Bandelow S, Combrinck M, Smith AD.
Low free testosterone is an independent risk factor for
Alzheimer's disease. Exp Gerontol. 2004
Nov-Dec;39(11-12):1633-9
60. Dimitrakakis C et al. Breast Cancer Incidence in
Postmenopausal Women Using Testosterone in Addition to
Usual Hormone Therapy. The Journal of the North
American Menopause Society 2004; 11(5): 531-535.
61. Davis S et al. Safety and Efficacy of a Testosterone
Metered-Dose Transdermal Spray for Treating Decreased
Sexual Satisfaction in Premenopausal Women. Annals of
Internal Medicine 2008; 148: 569-577
62. Burd ID, Bachmann GA. Androgen replacement in
menopause. Curr Womens Health Rep. 2001 Dec;1(3):202-5.
Review.
63. Braunstein
GD, Sundwall DA, Katz M, Shifren JL, Buster JE, Simon
JA, Bachman G, Aguirre OA, Lucas JD, Rodenberg C, Buch
A, Watts NB. Safety and efficacy of a
testosterone patch for the treatment of hypoactive
sexual desire disorder in surgically menopausal women: a
randomized, placebo-controlled trial. Arch Intern Med.
2005 Jul 25;165(14):1582-9.
64. Davis S, Simon J, Braunstein G, Nachtigall L, Utian W,
Katz M, Miller S, Waldbaum A, Bouchard C, Derzko C, Buch
A, Rodenberg C, Lucas J. Testosterone patch increases
sexual activity and desire in surgically menopausal
women with hypoactive sexual desire disorder. J Clin
Endocrinol Metab. 2005 Sep;90(9):5226-33. Epub 2005 Jul
12
65. Polotysky A, Santoro N. Menopause and Cardiovascular
Disease: Endogenous Reproductive Hormone Exposure
Affects Risk Factors. Menopause 2007.
66. Ross R et al. Effect of Hormone Replacement
Therapy on Brest Cancer Risk: Estrogen vs. Estrogen plus
Progestin. J Natl Cancer Inst 2000;92(4):328-332
67. Mead JH, Lommen ET. Slim, Sane & Sexy Pocket Guide to
Natural, Bioidentical Hormone Balancing Calaroga
Publishing, Oregon City, Oregon Copyright 2008 p. 43
Additional References
Davis SR. Postmenopausal hormone-replacement therapy. N Engl
J Med. 2002 Jan 3;346(1):63-5. No abstract available.
Davis SR. Determining the effects of androgen therapy on
sexual well-being: a complex challenge. Menopause. 2005
Jul-Aug;12(4):359-60. Epub 2005 Jul 21. No abstract
available.
Davis
SR, Dinatale I, Rivera-Woll L, Davison S.
Postmenopausal hormone therapy: from monkey glands to
transdermal patches.
J Endocrinol. 2005 May;185(2):207-22. Review.
Corrado F,
D'Anna R,
Caputo F,
Cannata ML,
Zoccali MG,
Cancellieri F.
Compliance with hormone replacement therapy in
postmenopausal Sicilian women.
J Womens Health (Larchmt).
2005 Jun;14(5):410-7.
Beral V,
Bull D,
Reeves G;
Million Women Study
Collaborators, Endometrial cancer and
hormone-replacement therapy in the Million Women Study.
Lancet. 2005
Apr 30-May 6;365(9470):1543-51.
Sitruk-Ware R.
New progestogens: a review of their effects in
perimenopausal and postmenopausal women.
Drugs Aging.
2004;21(13):865-83.
Erkkola R,
Kumento U,
Lehmuskoski S,
Mattila L,
Mustonen M,
No increased risk of endometrial hyperplasia with fixed
long-cycle oestrogen-progestogen therapy after five
years.
J Br Menopause Soc.
2004 Mar;10(1):9-13.
Palomba
S, Sena T, Noia R, Di Carlo C, Zullo F, Mastrantonio P.
Transdermal hormone replacement therapy in
postmenopausal women with uterine leiomyomas. Obstetrics
& Gynecology 2001; 98:1053-1058
Chen WY,
Hankinson SE,
Schnitt SJ,
Rosner BA,
Holmes MD,
Colditz GA;
Association of hormone replacement therapy to estrogen
and progesterone receptor status in invasive breast
carcinoma.
Cancer. 2004
Oct 1;101(7):1490-500.
Prasad R,
Boland GP,
Cramer A,
Anderson E,
Knox WF,
Bundred NJ;
Short-term biologic response to withdrawal of hormone
replacement therapy in patients with invasive breast
carcinoma.
Cancer. 2003
Dec 15;98(12):2539-46.
Kuttenn F, Gerson M. Hormone replacement therapy of
menopause, heart and blood vessels. Arch Mal Coeur Vaiss
2001;94:685-689.
Mendelsohn, ME, Karas, RH. Molecular and cellular basis of
cardiovascular gender differences; Science
2005;308:1583-7.
Estrogen Therapy Does Not Appear to Protect Postmenopausal
Women from Heart Disease. News From the AMA, Feb. 16,
2006
Hormone Replacement Therapy Increases Bone Mineral Density
In Frail Elderly Women. Journal of the American Medical
Association, August 15, 2001, Vol. 286, 815
Sitruk-Ware R. Progestins and cardiovascular risk models.
Steroids 2000; 65:651-658.
Gelfand MM,
et al. Clinical assessment and quality of life of
postmenopausal women treated with a new intermittent
progestogen combination hormone replacement therapy: a
placebo-controlled study. Menopause. 2003
Jul-Aug;10(4):373
Gelfand MM,
Ferenczy A.
A prospective 1-year study of estrogen and progestin in
postmenopausal women: effects on the endometrium.
Obstet Gynecol.
1989 Sep;74(3 Pt 1):398-402.
Rossouw J et al. Postmenopausal Hormone Therapy and Risk of
Cardiovascular Disease by Age and Years Since
Menopause. American Medical Association 2007; 297 (13):
1465-1477.
Both ET and EPT Appear To Increase The Risk of Ischemic
Stroke in Postmenopausal Women, But RCT Data Have Not
Been Bully Consistent In This Regard. North American
Menopause Society; Marcy/April 2007: 15.
Laumann EO,
Paik A,
Rosen
RC. Sexual dysfunction in the United States:
prevalence and predictors.
JAMA. 1999 Feb 10;281(6):537-44
Sarrel
PM.
Broadened spectrum of menopausal symptom relief.
J Reprod Med. 1998 Aug;43(8 Suppl):734-40
Basson
R. Female sexual response: the role of drugs in the management
of sexual dysfunction.
Obstet
Gynecol. 2001 Sep;98(3):522.